paradoxical disinhibition

paradoxical disinhibition

An unexpected increase in aggressiveness, hostility, impulsivity, or talkativeness in a patient after treatment with a tranquilizing drug, esp. a sedative/hypnotic.
See: paradoxical excitement
References in periodicals archive ?
Opioids most commonly inhibit release of neurotransmitters, particularly norepinephrine and acetylcholine, although in the hippocampus the result is paradoxical disinhibition, due to its impact on inhibitory interneurons.