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para-aminosalicylic acid

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para-aminosalicylic acid /para-ami·no·sal·i·cyl·ic ac·id/ (-ah-me″no-sal-ĭ-sil´ik) aminosalicylic acid.
par·a-a·mi·no·sal·i·cyl·ic acid (pr--mn-sl-slk)
n. Abbr. PAS, PASA
A bacteriostatic agent used against tubercle bacilli.

p-aminosalicylic acid (PAS) (PASA) [ah-me″no-sal-ĭ-sil´ik]
an analogue of p-aminobenzoic acid that inhibits folic acid synthesis in Mycobacterium tuberculosis, used in the treatment of tuberculosis, administered orally. In pharmacy it is officially called aminosalicylic acid. It enhances the potency of streptomycin and delays the development of bacilli resistant to streptomycin. Gastrointestinal irritation accompanied by anorexia, nausea, and vomiting may be reduced by administering the drug with food at mealtime.

para-aminosalicylic acid
see p-aminosalicylic acid.


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tuberculosis isolates resistant to streptomycin, 119 (65%) to ethambutol, 103 (56%) to rifabutin, 79 (43%) to pyrazinamide, 23 (13%) to amikacin, 20 (11%) to a fluoroquinolone, 19 (10%) to capreomycin, 36 (19%) to ethionamide, 15 (8%) to para-aminosalicylic acid, 9 (5%) to cycloserine, 3 (2%) to kanamycin, and 1 (<1%) to linezolid.
A daily regimen of 12,000 mg para-aminosalicylic acid, 800 mg ofloxacin, 750 mg cycloserine, 750 mg ethionamide, 150 mg thiacetazone, and 1,000 mg amikacin was administered for 2 years, with the diagnosis of multidrug-resistant tuberculosis.
On the basis of these results, on October 26, 2007, he was empirically prescribed a regimen of second-line drugs: capreomycin, para-aminosalicylic acid, cycloserine, ethionamide, and ciprofloxacin.
 
 
 
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