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panitumumab

   Also found in: Wikipedia 0.01 sec.
panitumumab,
a miscellaneous antineoplastic.
indications This drug is used to treat metastatic colon cancer expressing epidermal growth factor receptor.
contraindication Known hypersensitivity to this drug prohibits its use.
adverse effects Adverse effects of this drug include fatigue, ocular toxicity, peripheral edema, anorexia, mouth ulceration, abdominal pain, constipation, thrombophlebitis, pruritus, skin fissure, hypocalcemia, hypomagnesemia, antibody formation, dyspnea, pneumonitis, and wheezing. Life-threatening side effects include exfoliative dermatitis, bronchospasm, cough, hypoxia, and pulmonary fibrosis. Common side effects include nausea, diarrhea, vomiting, and rash.


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Analysis of K-RAS mutations in patients with metastatic colorectal cancer receiving panitumumab monotherapy.
Mechanistically, HER1 blockers, such as Genentech's erlotinib, AstraZeneca's gefitinib, ImClone's cetuximab and Amgen's panitumumab arrest and aggregate HER1 overexpressing cancer cells in the G1-Phase.
Cetuximab (a chimeric monoclonal immunoglobulin G1 antibody), the most advanced anti-EGFR agent in clinical development, and panitumumab (a fully human monoclonal immunoglobulin G2 antibody) are approved in Europe and in the United States (US) for the treatment of mCRC patients [13,14].
 
 
 
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