panacinar

panacinar

 [pan-as´ĭ-ner]
affecting many acini or alveoli.
References in periodicals archive ?
PROLASTIN - C and PROLASTIN are indicated for the treatment of alpha1-antitrypsin (AAT) deficiency in patients with panacinar emphysema.
Grade 2 was assigned for granules seen at X100 and present in greater than 50% of hepatocytes; grade 3, to discrete granules seen at X20 in zone 1 or panacinar, with zonal gradient across the acini; and grade 4, to blue granules seen by the naked eye and microscopically present within hepatocytes, with little or no gradient present.
Chest computed tomography scans revealed a panacinar emphysematous pattern predominantly in the lower lung fields associated with a ground glass opacity and alveolar hemorrhage in the left upper lobe consistent with contusion (Figure 2a-d).
Alpha 1 -Antitrypsin deficiency is a genetic defect that can lead to the development of severe panacinar emphysema.
Prolastin, Alpha1-Proteinase Inhibitor (Human), is indicated for chronic augmentation and maintenance therapy of individuals having congenital deficiency of alpha1 PI (alpha1-antitrypsin deficiency) with clinically demonstrable panacinar emphysema.
Depending on the anatomical location of airway destruction, emphysema can be classified into four major subtypes; centriacinar, panacinar, paraseptal and irregular (Kumar 2005).
Grading of NAFLD Grading of macrovesicular steatosis: Grade 0: None Grade l: Up to 33% Grade 2: 33-66% Grade 3: >66% Grading of nonalcoholic steatohepatitis: Mild (Grade) Steatosis- up to 66% Balloned hepatocytes-occasional (zone 3) Scattered infra-acinar neutrophils [+ or -] lymphocytes Portal inflammation - none or mild Moderate Steatosis- any degree (Grade II) Balloned hepatocytes-obvious (zone 3) Infra- acinar neutrophils ++ lymphocytes + Portal inflammation- mild to moderate Perisinusoidal zone III fibrosis Severe Steatosis- panacinar (Grade III) Balloned hepatocytes- widespread Infra-acinar neutrophils ++(associated with ballooned hepatocytes) f chronic inflammation Portal inflammation- mild to moderate Source: Ref.
Like PROLASTIN, PROLASTIN-C is indicated for the treatment of panacinar emphysema in patients with alpha1-antitrypsin (AAT) deficiency.
Trypsone is indicated for chronic augmentation and maintenance therapy in adults who have congenital AAT deficiency (phenotypes PiZZ, PiZ (Null), Pi (Null)(Null), PiSZ) with clinically demonstrable panacinar emphysema.
Like PROLASTIN, PROLASTIN-C is indicated for the treatment of alpha1-antitrypsin (AAT) deficiency in patients with panacinar emphysema.
PROLASTIN is indicated for chronic augmentation and maintenance therapy of individuals having congenital deficiency of A1PI (alpha1-antitrypsin deficiency) with clinically demonstrable panacinar emphysema.
and Canada for the treatment of panacinar emphysema in patients with AAT deficiency.