pain receptor


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Related to pain receptor: Chemoreceptors

pain receptor

any one of the many free nerve endings throughout the body that warn of potentially harmful changes in the environment, such as excessive pressure or temperature. The free nerve endings constituting most of the pain receptors are located chiefly in the epidermis and in the epithelial covering of certain mucous membranes. They also appear in the stratified squamous epithelium of the cornea, in the root sheaths and the papillae of the hairs, and around the bodies of sudoriferous glands. The terminal ends of pain receptors consist of unmyelinated nerve fibers that often anastomose into small knobs between the epithelial cells. Any kind of stimulus, if it is intense enough, can stimulate the pain receptors in the skin and the mucosa, but only radical changes in pressure and certain chemicals can stimulate the pain receptors in the viscera. Referred pain results only from stimulation of pain receptors located in deep structures, such as the viscera, the joints, and the skeletal muscles, and never from pain receptors in the skin.
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Pain reception pathway
References in periodicals archive ?
The "hot" compound in chili peppers, capsaicin, is already known to activate this pain receptor, called TRPV1 (transient receptor potential cation channel subfamily V member 1).
Her interpretation of the results is that in sensory nerves with both the chloroquine itch receptor and the wasabi pain receptor, when chloroquine binds to its receptor, it subsequently opens the wasabi receptor, which depolarizes the nerve cell and sends an itch signal to the brain.
Both itch inducers trigger the pain receptors through G protein couplings inside the cell.
Relaxation can promote natural endorphins that would block pain receptors and reduce the amount of pain that is experienced.
Botox (botulinum toxin) is believed to inhibit the release of peripheral nociceptive neurotransmitters - the pain receptors or nerve endings.
01, n=63) in the planned subset analysis of diabetic patients who had documented evidence of functioning pain receptors in the skin of the lower leg.
They believe this is done by slashing the animal's jugular vein in a way that cuts off oxygen to the brain and pain receptors.
There's something about this increased flow to the brain that activates the pain receptors.
There is a distinct possibility that, during certain times in some children's growth phases, the tension across the epiphyseal plate may be released in a manner similar to a microscopic "earthquake", placing increasing tension on the periosteum, thereby triggering the firing of the pain receptors that reside in this tissue.
Researchers at the Harvard University recently announced that they believe 'capsaicin' can be used to target pain receptors, without affecting nerve cells or causing side effects mentioned above, which is a big plus.
Colgate describes its Pro-Argin[TM] Technology as comprised of an amino acid, arginine and an insoluble calcium compound, calcium carbonate, to seal open dentin tubules and help block stimuli of pain receptors within teeth.
These products may modulate the human immune system, but they are also being studied for related effects on infections, inflammation, and pain receptors.