pain receptor


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pain receptor

any one of the many free nerve endings throughout the body that warn of potentially harmful changes in the environment, such as excessive pressure or temperature. The free nerve endings constituting most of the pain receptors are located chiefly in the epidermis and in the epithelial covering of certain mucous membranes. They also appear in the stratified squamous epithelium of the cornea, in the root sheaths and the papillae of the hairs, and around the bodies of sudoriferous glands. The terminal ends of pain receptors consist of unmyelinated nerve fibers that often anastomose into small knobs between the epithelial cells. Any kind of stimulus, if it is intense enough, can stimulate the pain receptors in the skin and the mucosa, but only radical changes in pressure and certain chemicals can stimulate the pain receptors in the viscera. Referred pain results only from stimulation of pain receptors located in deep structures, such as the viscera, the joints, and the skeletal muscles, and never from pain receptors in the skin.
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Pain reception pathway
References in periodicals archive ?
If sensory nerves contain pain receptors like TRPA1 and TRPV1, and itch receptors like MrgprA3 and MrgprC11, how does the cell distinguish between itch and pain?
Botox (botulinum toxin) is believed to inhibit the release of peripheral nociceptive neurotransmitters - the pain receptors or nerve endings.
at the place of pain receptors localization their stimulation occurred that explains intensity of the pain syndrome at the initial period, as well as by large volume of hematoma in this time.
Drugs act on chemicals produced by the pain receptors and, in so doing, often relieve pain.
Researchers at the Harvard University recently announced that they believe 'capsaicin' can be used to target pain receptors, without affecting nerve cells or causing side effects mentioned above, which is a big plus.
Colgate describes its Pro-Argin[TM] Technology as comprised of an amino acid, arginine and an insoluble calcium compound, calcium carbonate, to seal open dentin tubules and help block stimuli of pain receptors within teeth.
These products may modulate the human immune system, but they are also being studied for related effects on infections, inflammation, and pain receptors.
This includes discussion of functional heartburn, pain receptors, neutral reflux in typical and atypical GERD symptoms, and molecular pathways and cortical processing.
The results of the study led by Mark Wallace, Professor of Clinical Anesthesiology at the Center for Pain Medicine of the University of California at San Diego, suggested that NGX426 could be effective in a variety of neuropathic pain states, which are caused by damage to or dysfunction of the peripheral or central nervous system rather than stimulation of pain receptors.
It doesn't interact with your taste buds but instead, with the pain receptors in your mouth
With Enkephalin, GAD and Endomorphin, we have completed our pain portfolio now having products targeting all three major pain receptors.
Adenosine is released as part of the inflammatory response to injury and can activate pain receptors in body cells.