pain modulation

pain modulation

Neurology An ↑ or ↓ of the sensation of pain, possibly due to a 2º neural pathway. See Opioid-mediated analgesia system.
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Thus far, it appears that Kalytera's compounds interact with CB2 receptors, which are believed to play an important role in the immune system, inflammation, and pain modulation.
A case-control study design with repeated measures and real-time monitoring of various autonomic parameters was used to evaluate whether patients with acute WAD show a dysfunctional autonomic response to pain compared with patients with chronic WAD and healthy controls and whether autonomic reactivity to pain is related to conditioned pain modulation (CPM) of heterotopic noxious conditioning stimulation in people with acute WAD.
It will also be used for tests of pain modulation including facilitation and inhibition.
PHOENIX, March 7, 2014 /PRNewswire-USNewswire/ -- Researchers have demonstrated that conditioned pain modulation (CPM), a measure of the brain's ability to regulate pain, decreases activity in the human spinal cord as visible via functional magnetic resonance imaging (fMRI).
Because the endocannabinoids play an important role in pain modulation, trans-caryophyllene may hold promise as a new pain treatment.
The periaqueductal gray (PAG), dorsolateral pontine tegmentum (DLPT), and rostroventral medulla (RVM) are the key regions of the brain involved in this descending pain modulation.
Tricyclic antidepressants are also effective for pain modulation due to their ability to decrease serotonin and norepinephrine reuptake in the central nervous system and to stabilize mast cells; they also have a moderate anti-cholinergic effect.
The regions associated with pain modulation are the cingulo-frontal cortex and periaqueductal gray matter.
Revised, this edition includes 13 new chapters on central pain modulation, ultrasound-guided procedures, myelopathy, and other topics.
Compared with healthy controls, chronic pain sufferers had thinning in a brain region that's been linked to pain modulation, the left dorsolateral prefrontal cortex.
Tricyclic antidepressants have potential value in these disorders because of their central and peripheral effects on pain modulation and motility.
Analyses of regional gray matter density showed that the regions of gray matter loss were those associated with pain modulation or stress, including the cingulate, insular, and medial frontal cortices, parahippocampal gyri, and thalamus.