2] Histologically, pagetoid BD is characterized by nests of atypical keratinocytes with round nuclei and abundant pale cytoplasm located either singularly or in groups within the epidermis, and the main differential diagnosis of pagetoid cells
includes extra-mammary pagetoid disease (EMPD) and malignant melanoma in situ (MIS).
7] When these pagetoid cells are unusually abundant, they may cause concern in inexperienced pathologists.
We have recently observed several cases with pagetoid cells in the squamous epithelium of surgically resected hemorrhoids.
Pagetoid cells were more numerous in the parabasal and midzone layers than in the superficial layers of the squamous epithelium.
The pagetoid cells did not stain with special stains such as periodic acid-Schiff, Alcian blue, Mayer mucicarmine, and Fontana-Masson silver.
The term pagetoid cells includes all discrete non-malpighian or abnormal malpighian intraepidermal cells that resemble cells of Paget disease occurring singly or in small groups in the squamous epithelium.