DOK1

(redirected from p62)

DOK1

A gene on chromosome 2p13 that encodes an enzymatically inert adaptor/scaffolding protein, which provides the docking platform for assembling multimolecular signalling complexes. DOK1 modulates integrin activation by competing with talin for the same binding site on ITGB3, and may be a negative regulator of the insulin signalling pathway. It is expressed in the pancreas, heart, leukocytes and spleen.
References in periodicals archive ?
Results: Exposure to GUTK was observed to markedly induce GFP-LC3 puncta formation and activate the accumulation of LC3-II and the degradation of p62 in HeLa cells, suggesting that GUTK is an autophagy inducer.
These novel p62 inhibitors demonstrate inhibition of multiple myeloma cell growth without toxicity to normal bone marrow stromal cells.
Tau immunostains will highlight the abnormally phosphorylated tau deposits in neurons and glia that are found in FTLD-tau; ubiquitin or p62 immunostains will highlight the abnormal protein deposits in neurons and glia found in FTLD-U; and TDP-43 will demonstrate whether or not the ubiquitin or p62 immunopositive, tau-negative inclusions are those of FTLD-TDP, the most common FTLD-U.
Washington, January 5 ( ANI ): Something more than overeating and a lack of exercise causes the body to store more fat and burn less energy - a protein called p62, researchers have claimed.
Combined with cost increases in soya, corn and other commodity raw materials which heavily affected the chicken business, the Food Group's operating income decreased by 66% from P186 million in 1999 to P62 million ($1.
WHERE TO BUY: see p62 NB: We've listed the official RRPs, but there are loads of good summer offers at Boots, Marks & Spencer and supermarkets
With the inclusion of our new P62 Multiple Myeloma Therapeutics platform, we are posed to be a significant player in the large and expanding market for Myeloma Therapeutic drug therapies.
They also bred mice with the p62 mutation and MVNP.
The studies were based on the knowledge that P62 plays critical roles in the survival, growth and metastasis of multiple myeloma cells.
Full story: p62 PLUS: It's comeback kid Skrtel Page 62/3
Oct 29-Nov 4, 2011 WIN P29 CONTENTS p34 lisTiNgs FUN P62 FEATURES P4-13 SOAPS P16-23 REAL LIFE P27 MOVIES P31 We lovetelly Supplements Editor: Tony Stewart Chief Sub-Editor: Ian Sturgess Features Editor: Jennifer Rodger Feature Writer: Sara Wallis Art Editor: Jason Gray Art Director: Annie Roth Picture Editor: Kirsty Barclay Assistant Picture Editor (Research): Joanna Hargreaves TV Listings Editor: Ed Keenan Colour correction: Mirror Image Quality Dept We Love Telly is published by MGN Ltd [umlaut] MGN Ltd.