A cyclin-dependent kinase inhibitor which binds to cyclinE/cdk2, blocking the G1/S transition step required for cell cycle progression. It is upregulated by cell stress, resulting in inhibition of cell cycling and apoptosis, and may have a role in tumour supression, cell migration and mitosis; low p27 expression has been reported in breast, colourectal, gastric, lung and brain cancer. Decreased p27 expression is associated with a poorer prognosis. p27 is downregulated through degradation by ubiquitin-dependent proteolysis
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Mammalian target of rapamycin (mTORc1), Jagged 1, Jagged 2, Notch 1, Notch receptor intracellular domain (NICD), and p27kip1 antibodies were from Santa Cruz Biotechnology (USA).
Reduced expression of the cell-cycle inhibitor p27Kip1 is associated with progression and lymph node metastasis of gastric carcinoma.
Transcription factors such as p53, v-myc avian myelocytomatosis viral oncogene homolog (MYC), myoblast determination protein 1 (MYOD1), zinc finger E-box binding homeobox (ZEB) 1 and 2, and p27Kip1 (cyclin-dependent kinase inhibitor 1B) regulate the transcription of miR-34, miR-17, miR-1, miR-15a, miR-200, and miR-221 which play an important role in prostate cancer as either tumor promoters or tumor suppressors (7-11) (Fig.
Clinicopathological comparison of adenocarcinoma of cervix and endometrium using cell cycle markers: p16ink4a, p21waf1, and p27Kip1 on 132 cancers.
24,25) Further investigation led to the surprising discovery that K17 is able to enter the nucleus of cancer cells, where it binds to and ultimately causes the degradation of p27KIP1, an important regulator of early (G1) cell cycle arrest.
FoxO3a preferentially induces p27Kip1 expression while impairing muscle precursor cell-cycle progression.
MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1.
Down-regulation of p27Kip1 has been shown to correlate with histologic loss of differentiation or high-grade morphology in various human carcinomas (192-196) and is emerging as an important prognostic factor.
Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: Role of exogenous dietary fatty acids, p53p21 WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB.
It induces apoptosis via the up-regulation of p27Kip1, therefore arresting cancer cells in G1 phase [12].
Clinical significance of cyclin-dependent kinase inhibitor p27Kip1 expression and proliferation in non-Hodgkin's lymphoma: independent prognostic value of p27Kip1.
Hormone-induced proliferation and differentiation of granulosa cells: a coordinated balance of the cell cycle regulators cyclin D2 and p27Kip1.