p27kip1

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p27kip1

A cyclin-dependent kinase inhibitor which binds to cyclinE/cdk2, blocking the G1/S transition step required for cell cycle progression. It is upregulated by cell stress, resulting in inhibition of cell cycling and apoptosis, and may have a role in tumour supression, cell migration and mitosis; low p27 expression has been reported in breast, colourectal, gastric, lung and brain cancer. Decreased p27 expression is associated with a poorer prognosis. p27 is downregulated through degradation by ubiquitin-dependent proteolysis

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No references found			Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1. The drug virtually everyone should ask their doctor about by Goepp, Julius / Life Extension Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression. Molecular biology underlying the clinical heterogeneity of prostate ... by Mackinnon, A. Craig; Yan, Benjamin C.; Joseph, Loren J.; Al-Ahmadie, Hikmat A. / Archives of Pathology & Laboratory Medicine p21WAF1 (p21) and p27KIP1 (p27) are both universal inhibitors of cyclin-dependent kinases and can therefore influence cell cycle or tumor progression. Cell cycle alterations in endometrial carcinoma by Bovicelli, Alessandro; D'Andrilli, Giuseppina; Giordano, Antonio / Experimental Medicine			P-R interval P-sinistrocardiale p-type semiconductor p-value P. ovale p.ae p.c p.c. P.C.P P.D P.I P.M.D p.o p.o. p.r.n p.r.n. p.s.i p.s.i. P.U.O P1 p17 P1E1 P2 p24 p24 antigen p27kip1 P50 p53 PA PA inhibitor PA interval PA skull Paatsama technique PAB PAB, PABA PABA pabulin pabulum PAC PAC-A-TACH paca pacchionian pacchionian body pacchionian depression pacchionian foramen pacchionian granulations PACE PACE II paced respiration pacefollower pacemaker			P1E P1E1 P1I P1S P1S2E P1W P2 P2 P2 P2 (disambiguation) P2 (disambiguation) P200 P21-Activated Kinase P21-Activated Kinase 1 P21-Activated Kinase 2 P21-Activated Kinase 6 P21-Activated Kinase 7 P220 P23 P24 P24 p24 antigen p24 antigen detection after immune complex dissociation P24 antigen test p24-ICD P24T P25 P27 p27kip1 P28T P2A P2AD P2ADS P2B P2BPK p2c p2c P2C2 P2C2E P2C4I P2D P2D2 P2E P2E1 P2E2 P2F2 P2G P2I P2IC P2IF P2K P2L P2M P2MP

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