p21


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CDKN1A

A gene on chromosome 6p21.2 that encodes a cyclin-dependent kinase inhibitor, which binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, thus acting as a regulator of cell cycle progression at G1. CDKN1A expression is controlled by p53, a tumour suppressor that mediates p53-dependent cell cycle G1-phase arrest in response to various stress stimuli. CDKN1A is specifically cleaved by CASP3-like caspases, activating CDK2 and possibly also the apoptosis pathway.

p21

Also known as p53 protein, an anticancer protein of the class of cyclin-dependent kinase inhibitors. Cyclin-dependent kinases are enzymes that have been described by Elizabeth Finkel as ‘the engines that drive the cell-cycle past its various control checkpoints.’ Inhibition of these enzymes provides a way of controlling rapidly-reproducing cells such as cancer cells. High levels of p21 are found in ageing cells. p21 protein is dysfunctional in most human cancers.
References in periodicals archive ?
1, 2015 /PRNewswire/ -- Sixteen schools and 3 districts nationwide have been selected by P21, the Partnership for 21st Century Learning as 21st Century Learning Exemplars for 2016.
Wild-type P53, a nuclear phosphoprotein, has been shown to be a sequence specific transcription factor which induces the expression of P21, WAF1/C1 P1/Sdi-1, leading to a G1 arrest checkpoint to step up repair before DNA replication and contributes to normal cell proliferation; unless DNA replication is successful, the cells will be induced to undergo apoptosis.
Design_atelier_, part of Kalimat Magazine, is organising an exhibition of local talented artists to be shown in London at the P21 Gallery.
RichardJMoir Andrew Haines 2013: P21 W3 D3 L15 F16 A37 Pts 12 GD -21 #embarrassed @BoroinBucks Razmoo ALL Boro players that have been part of this season's shambles - I hope you have the bottle to apologise to the fans who pay your wages.
In the past 10 years, starting with the 2002 series against Sri Lanka, their record is P21 W15 D5 L1.
P21 GmbH, a subsidiary of Heliocentris Energy Solutions, has been awarded another order from the du, to implement its 'Genset Efficiency' solution in 57 additional mobile network base station sites.
The team at Northwestern University Feinberg School of Medicine has identified this bouncer, a protein called P21, which prevents immune cells from launching into their destructive rampage through the cartilage and bone.
The Role of Career and Technical Education and 21st Century Skills in College and Career Readiness," ACTE, NASDCTEc and P21 explore shared understandings and common strengths of CTE and P21 efforts, emphasizing that: "Integrating 21st century skills and CTE into the entire education system will put more students on the path to success.
The heart of that strategy is to wrap P21 around the effort to get states to adopt a set of national K-12 education standards, known as the Common Core.
Much of the impetus came from the P21 board, which includes representatives from educational foundations and corporations, including Intel, Hewlett-Packard, Cisco and Microsoft.
German fuel cell systems manufacturer P21 will provide two fuel cell systems for testing to a large South African mobile network operation, the company announced this week.
com/research/k6qwbl/impact_of_lift_and) has announced the addition of the "Impact of Lift and P21 on Healthcare Construction Market Report - UK 2012-2016 Analysis" report to their offering.