oxyntomodulin


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oxyntomodulin

(ŏk-sĭn″tō-mŏj′ū-lĭn)
A 37-amino acid peptide secreted by the small intestine. It inhibits gastric acid secretion and reduces food intake.
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Measures Glucagon (1-29) with no detectable cross-reactivity to Glicentin, Oxyntomodulin, GLP-1, GLP-2, or GRPR Sensitive to 2.
In addition, OPKO Health's biologics business includes hGH-CTP, a once-weekly human growth hormone injection (in Phase 3 and partnered with Pfizer), a long-acting Factor VIIa drug for hemophilia (in Phase 2a) and a long acting oxyntomodulin for diabetes and obesity (in Phase 1).
glicentin, oxyntomodulin, GLP-1 and GLP-2 derived from proglucagon
Several hormones secreted in the gut have anorexigenic effects, including cholecystokinin (CCK), pancreatic polypeptide, peptide tyrosine-tyrosine (PYY), GLP-1, and oxyntomodulin, whereas ghrelin has an orexigenic effect.
They argue that the favorable effects of bariatric surgery are at least partially related to changes of gut hormones such as GLP-1, PYY, PP and oxyntomodulin, as well as changes in the ghrelin system.
Bloom found a chemical, oxyntomodulin, along with saline (sodium and water) and peptides, which is required to jumpstart the metabolism, contributing to weight loss.
As food enters your stomach it stimulates production of two hormones - peptide YY and oxyntomodulin - that create a feeling of satiety," she explains.
Oxyntomodulin increases the concentrations of insulin and glucose in plasma but does not affect ghrelin secretion in Holstein cattle under normal physiological conditions.
According to its inventor, Professor Stephen Bloom, a world-leading expert in obesity based at Imperial College London, the drug works by mimicking a gut hormone, oxyntomodulin that the body makes when it has had enough to eat.
A Columbia University team reported last year in the Journal of Clinical Endocrinology & Metabolism that levels of a digestive hormone and appetite inhibitor called oxyntomodulin are doubled in diabetic gastric bypass patients only one month after surgery, whereas similarly obese people who lost weight by dieting saw no increase.
The drug, TKS1225, and related compounds are synthetic versions of a natural peptide--or protein fragment--found in the gastrointestinal system and called oxyntomodulin.
Researchers have also discovered that topping up levels of oxyntomodulin - a naturally acting digestive hormone - tricks the body into thinking it is full, thus reducing the appetite.