oxygen-derived free radicals

ox·y·gen-de·rived free rad·i·cals

an atom or atom group having an unpaired electron on an oxygen atom, typically derived from molecular oxygen. For example, 1-electron reduction of O2 produces the superoxide radical, Ō2·; other examples include the hydroperoxyl radical (HOO·), the hydroxyl radical (HO·), and nitric oxide (NO·). These apparently have a role in reprofusion injury.

ox·y·gen-de·rived free rad·i·cals

(ok'si-jĕn dĕ-rīved' frē rad'i-kălz)
An atom or atom group having an unpaired electron on an oxygen atom, typically derived from molecular oxygen. For example, one-electron reduction of O2 produces the superoxide radical, Ō2•; other examples include the hydroperoxyl radical (HOO•), the hydroxyl radical (HO•), and nitric oxide (NO•). These apparently have a role in reperfusion injury.
References in periodicals archive ?
Oxygen-derived free radicals can either depress directly contraction or lead to apoptosis.
Because oxygen-derived free radicals are believed to have an important role in the pathogenesis of many diseases, Aeolus' catalytic antioxidants are believed to have a broad range of potential therapeutic uses.
Oxygen-derived free radicals play an important role in the initiation and progress of all clinically manifested aspects of ischemic heart disease.
These data imply that bilirubin may be consumed in response to the generation of oxygen-derived free radicals, supporting an active clinical role for bilirubin as an antioxidant.
allopurinol) had antioxidant properties, binding these oxygen-derived free radicals before they could do their dirty work.
The high consumption of oxygen bathes the body in biologically damaging, oxygen-derived free radicals.
Because oxygen-derived free radicals are believed to have an important role in the pathogenesis of many diseases, Aeolus' antioxidant enzyme-mimetic drugs are believed to have a broad range of potential therapeutic uses.
Because oxygen-derived free radicals are believed to be an important contributor to the pathogenesis of many diseases, these antioxidant mimetic drugs have a broad range of potential therapeutic uses.
Incara is developing a new class of small molecule catalytic antioxidants that destroy oxygen-derived free radicals, believed to be an important contributor to the pathogenesis of many diseases.
com/ ) is developing a new class of small molecule catalytic antioxidants that destroy oxygen-derived free radicals, believed to be an important contributor to the pathogenesis of many diseases.
Duke Professor of Biochemistry, Emeritus, at Duke University Medical Center and was a co- discoverer of superoxide dismutase, one of the body's key defenses against the damaging effects of oxygen-derived free radicals.
AEOL10150, our IND candidate, decomposes a variety of oxygen-derived free radicals, protects spinal neurons, and dramatically prolongs survival in the mouse model.

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