oxindole


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oxindole

(ŏk′sĭn-dōl)
Natural derivatives of tryptophan that are present in high concentrations in the brains of patients with hepatic encephalopathy. Chemicals from this class have sedative and antioxidant effects. Some evidence suggests oxindoles may be useful in the treatment of Alzheimer's dementia.
References in periodicals archive ?
Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human Ewing's sarcoma and breast cancer cell lines.
a novel spiro oxindole, welwitindolinone A isonitrile (59), five tetracyclic oxindoles, and eight biogenetically related fischerindoles and hapalindoles.
Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells.
50] values were calculated for different oxindole alkaloid compositions.
Cat's claw (Uncaria tomentosa), an herb from the Amazon rainforest, contains an oxindole alkaloid of particular interest to scientists looking for Alzheimer solutions.
The active principles thought to be responsible for these effects are pentacyclic oxindole alkaloids (POA).
Chemistry: family producing iridoids and alkaloids (of indole & oxindole types) notable amongst these being the tryptophanic alkaloids, rarely saponiferous, sometimes accumulating aluminum.
Uncaria tomentosa another ingredient present in ImmuneRich, also known as Cat's Claw contains oxindole alkaloids that have immune function enhancement properties.
These include 5 pentacyclic oxindole alkaloids (P0As) and 4 tetracyclic oxindole alkaloids (TOAs).
Scientists previously attributed the efficacy of cat's claw to compounds called oxindole alkaloids; (1) more recently, however, water-soluble cat's claw extracts that do not contain significant amounts of alkaloids were found to possess strong antioxidant and anti-inflammatory effects.
24 /PRNewswire/ -- While combing through hundreds of cat's claw products in the supplement aisle, you're not likely to find this important label claim -- 100% tetracyclic oxindole alkaloid free.