oxidized phospholipids

oxidized phospholipids

Fatty acids bound to a glycerol molecule containing a polar head group, which have been subjected to oxidation by free radicals or enzymes such as myeloperoxidase and lipoxygenase. They are proinflammatory and are believed to play an important part in the aetiology of atherosclerosis.
References in periodicals archive ?
Methodology for detecting and quantifying oxidized phospholipids is advancing rapidly, and will be continually refined as mass spectroscopy techniques improve.
In addition, reductions in low-density lipoprotein-cholesterol - (LDL-C) and pro-inflammatory oxidized phospholipids were observed, as well as a decrease in the inflammatory effects of white blood cells, which can initiate and accelerate cardiovascular disease.
Evidence exists that HDL can reverse LDL oxidation by removing the oxidized phospholipids that make LDL harmful and lead to atherogenesis [42].
sup][27] A deficiency of PON1 enhanced atherosclerosis in hypercholesterolemic mice and was associated with an increase in oxidized phospholipids.
Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease.
This particle's function remains largely uncertain; Lp(a) binds proinflammatory-oxidized phospholipids (11) and is a preferential carrier of oxidized phospholipids (ox-PL) in human plasma.
showed that human PON1 could inhibit LDL oxidation in vitro, prevents formation of oxidized LDL and protects phospholipids in HDL from oxidation by inactivating LDL-derived oxidized phospholipids (11).
Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an enzyme that hydrolyzes oxidized phospholipids, releasing lysophosphatidylcholine, which has proinflammatory properties thought to be involved in the development of atherosclerosis and plaque rupture.
1 Recent studies have indicated that oxidized phospholipids can down-regulate the production of pro-inflammatory cytokines.
Genetic elimination of autophagy resulted in massive accumulation of protein aggregates in stressed cells, elevation of Nrf2 target gene expression, and strikingly a significant rise in various oxidized species of phospholipids, implying that during homeostasis autophagy prevents accumulation of oxidized phospholipids, as well as overexpression of Nrf2 target genes in keratinocytes [57].
Objective: MASSTRPLAN will train the next generation of interdisciplinary research leaders in advanced molecular analytical techniques to detect oxidized phospholipids & proteins in biological & clinical samples, evaluate their biochemical roles in inflammation, and translate these findings to develop new diagnostic tools.