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a topical antifungal agent used as the nitrate salt in treatment of athlete's foot and ringworm.


(ox-i-kon-a-zole) ,


(trade name)


Therapeutic: antifungals
Pregnancy Category: B


Treatment of a variety of cutaneous fungal infections, including tinea pedis (athlete’s foot), tinea cruris (jock itch), tinea corporis (ringworm), and tinea versicolor (cream only).


Affects the synthesis of the fungal cell wall.

Therapeutic effects

Decrease in symptoms of fungal infection.


Absorption: Absorption through intact skin is minimal.
Distribution: Distribution after topical administration is primarily local.
Metabolism and Excretion: Systemic metabolism and excretion not known following local application.
Half-life: Not applicable.

Time/action profile



Contraindicated in: Hypersensitivity to active ingredients, additives, preservatives, or bases.
Use Cautiously in: Nail and scalp infections (may require additional systemic therapy); Obstetric / / Lactation: Safety not established.

Adverse Reactions/Side Effects


  • burning
  • itching
  • local hypersensitivity reactions
  • redness
  • stinging


Drug-Drug interaction

Not known.


Topical (Adults and Children) Apply cream or lotion once or twice daily in patients with tinea pedis, tinea corporis, or tinea cruris. Apply cream once daily in patients with tinea versicolor. Patients with tinea corporis, tinea cruris, or tinea versicolor should be treated for 2 wk. Patients with tinea pedis should be treated for 4 wk.


Cream: 1%
Lotion: 1%

Nursing implications

Nursing assessment

  • Inspect involved areas of skin and mucous membranes before and frequently during therapy. Increased skin irritation may indicate need to discontinue medication.

Potential Nursing Diagnoses

Risk for impaired skin integrity (Indications)
Risk for infection (Indications)


  • Consult physician or other health care professional for proper cleansing technique before applying medication.
    • Lotion is usually preferred in intertriginous areas; if cream is used, apply sparingly to avoid maceration.
  • Topical: Apply small amount to cover affected area completely. Avoid the use of occlusive wrappings or dressings unless directed by physician or other health care professional.

Patient/Family Teaching

  • Instruct patient to apply medication as directed for full course of therapy, even if feeling better. Emphasize the importance of avoiding the eyes.
  • Caution patient that some products may stain fabric, skin, or hair. Check label information. Fabrics stained from cream or lotion can usually be cleaned by handwashing with soap and warm water.
  • Patients with athlete’s foot should be taught to wear well-fitting, ventilated shoes, to wash affected areas thoroughly, and to change shoes and socks at least once a day.
  • Advise patient to report increased skin irritation or lack of response to therapy to health care professional.

Evaluation/Desired Outcomes

  • Decrease in skin irritation and resolution of infection. Early relief of symptoms may be seen in 2–3 days. For tinea cruris, tinea corporis, and tinea versicolor, 2 wk are needed, and for tinea pedis, therapeutic response may take 4 wk. Recurrent fungal infections may be a sign of systemic illness.


/ox·i·con·a·zole/ (ok″sĭ-kon´ah-zōl) an imidazoleantifungal used topically as the nitrate salt in the treatment of various forms of tinea.


a topical antifungal agent used as the nitrate salt in treatment of athlete's foot and ringworm.
References in periodicals archive ?
3% Terbinafine 38% 59% 70% TABLE 3 Agents Available for the Treatment of Tinea Pedis Agent Formulation(s) Mycological Cure Naftifine 2% Cream, gel Once a day x 2 weeks Luliconazole 1% Cream Once a day x 2 weeks Terbinafine 1% Cream, gel, spray Once a day x 1-4 weeks (gel) Twice a day x 1-4 weeks (cream, spray) Butenafine 1% Cream Once a day x 4 weeks Oxiconazole 1% Cream, lotion Once/twice a day x 4 weeks Naftifine 1% Cream, gel Once a day x 4 weeks (cream) Twice a day x 4 weeks (gel) Econazole 1% Cream, foam Once a day x 4 weeks Tolnaftate 1 % Cream, gel, Twice a day x 2-6 weeks powder, spray Sertaconazole Cream Twice a day x 4 weeks nitrate 2% Ciclopirox 0.
azole antifungals in this pharmacologic class: clotrimazole (Lotrimin), econazole (Spectazole), ketoconazole (Kuric), miconazole (Micatin), oxiconazole (Oxistat), sertaconazole (Ertaczo), and sulconazole (Exelderm).
They can be treated with topical drugs, including clotrimazole, econazole, oxiconazole, ciclopirox, terbinafme, and ketoconazole.
I treat the areas between the toes with oxiconazole nitrate cream, I wash vigorously to remove loose skin cells, and I even use separate foot towels to dry off.
They can be treated with a wide variety of topical drugs, among them clotrimazole, econazole, oxiconazole, ciclopirox, terbinafine, and ketoconazole.
Options include econazole, ketoconazole, oxiconazole, and sulconazole.
He singled out oxiconazole, the first topical antifungal approved for once-daily use, as particularly useful.
The fungicidal allylamines (naftifine and terbinafine) and butenafine (allylamine derivative) are a more costly group of topical tinea treatments, yet they are more convenient as they allow for a shorter duration of treatment compared with fungistatic azoles (clotrimazole, econazole, ketoconazole, oxiconazole, miconazole, and sulconazole).
In Switzerland, three triazoles (terconazole, itraconazole, fluconazole) and eight imidazoles (clotrimazole, miconazole, econazole, ketoconazole, tioconazole, isoconazole, oxiconazole, and fenticonazole) are in use (Documed AG 2002).
Topical members of this class are clotrimazole, miconazole, econazole, ketoconazole, oxiconazole, and sulconazole.
All the topical "-azoles," including econazole nitrate, ciclopirox olamine, and oxiconazole nitrate, appear to be equally effective in the treatment of tinea versicolor, although none has been studied as thoroughly as ketoconazole cream.