overexpress

overexpress

(ō″vĕr-ek-spres′)
1. To transcribe and translate more genetic product than normal. The process is a characteristic of cancer cells.
2. To display more antigenic markers on a cell surface than are normally seen.
References in periodicals archive ?
Women with TNBC whose tumors overexpress FIAS2 have a significantly reduced survival, so that targeting this gene is likely to have an impact on disease progression," says Welsh.
To look specifically at the impact on bone loss, the researchers crossed mice bred to overexpress tumor necrosis factor alpha throughout the body with mice that overexpressed GILZ in just their mesenchymal stem cells.
This open-label, multi-dose, single-arm, multi-center Phase I, dose-escalation study is being conducted to define the toxicity profile, maximum tolerated dose, pharmacokinetics, immunogenicity, and potential antitumor activity of MGAH22 in patients with refractory HER2-positive breast cancer and patients with other carcinomas that overexpress HER2 for whom no standard therapy is available.
They estimate that 10% of women with breast cancer overexpress the FGFR1 gene.
The microorganisms produce the desired L-amino acid and overexpress the E.
Future studies will overexpress DNA binding, non DNA binding, and alanine/aspartate mutant IK isoforms to determine their effect on IK binding.
In tumours that overexpress the HER2 gene, targeted therapy against HER2, including lapatinib and trastuzumab, has proved very fruitful but there are a few options for oestrogen receptor-negative HER2-negative breast cancer.
Trastuzumab, sold under the name Herceptin, is a recombinant monoclonal antibody that slows or stops the growth of cancers that overexpress the HER-2 protein.
Rabinovitch of the University of Washington in Seattle and his colleagues genetically engineered mice to overexpress a gene responsible for making the antioxidant called catalase.
The investigators also intend to construct derivatives of Lactobacillus helveticus CNRZ32 that overexpress specific esterase activity.
About 20 percent of women with ovarian cancer overexpress the HER2 gene and the drug may prove effective for women with that disease.
They bred the B-catenin colon cancer mice with mice that overexpress the SIRT1 enzyme in the gut.