Many factors affecting mesenchymal and osteoprogenitor cell
proliferation have been determined in serum after TBI, however, the results are controversial, and ossification and CNS damage are linked to an accidental association (30).
Reid, MD, PhD, a leading researcher in craniofacial disorders at the University of Chicago Medical School utilized BioElectronics' ActiPatch to transform two cell lines of pluripotent osteoprogenitor cells
Bone marrow aspiration is an inefficient method of obtaining osteoprogenitor cells
because most aspirates are largely red blood cells.
Also cells activated by TGF[beta]1 and TGF[beta]2 include fibroblasts, endothelial and osteoprogenitor cells
, chondroprogenitor cells and mesenchymal stem cells.
The membrane facilitates osteoprogenitor cells
originating from adjacent healthy bone to repopulate and produce new bone material.
Geron scientists and collaborators presented data at the International Society for Stem Cell Research's (ISSCR) annual meeting pertaining to four products in development: (1) GRNOPC1, Oligodendroglial Progenitor Cells for acute spinal cord injury; (2) GRNIC1, Islet Clusters to treat patients with Type 1diabetes; (3) GRNCM1, Cardiomyocytes for patients who suffered a myocardial infarction and (4) osteoprogenitor cells
for bone fractures and osteoporosis.
Presented by Geron scientists and collaborators at the International Society for Stem Cell Research's (ISSCR) annual meeting in Toronto, the data pertained to four products in development: (1) GRNOPC1, Oligodendroglial Progenitor Cells for acute spinal cord injury, (2) GRNIC1, Islet Clusters for diabetes, (3) GRNCM1, Cardiomyocytes for myocardial infarction and (4) osteoprogenitor cells for bone fractures and osteoporosis.
As our work progresses with other hESC-derived cell types such as cardiomyocytes, islets, hepatocytes and osteoprogenitor cells, we are hopeful that these cell types will also demonstrate significant, long-term regenerative capacity in animal models, setting the stage for clinical trials in patients.
An interconnecting 90% porous structure with a range of pore sizes, from 1mm to sub-micron works to wick and hold osteoprogenitor cells
contained in the marrow and provides the ideal architecture to allow for the revascularization and healing throughout the graft.