osteopontin


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Related to osteopontin: Osteocalcin, Osteonectin

os·te·o·pon·tin

(os'tē-ō-pon'tin),
A secreted phosphoprotein, produced by many epithelial cell types, which is highly negatively charged and frequently associated with mineralization processes. It is found in plasma, urine, milk, and bile. Transformed cells express osteopontin in elevated levels.
Synonym(s): bone sialoprotein 1

osteopontin

(ŏs′tē-ō-pŏn′tn)
n.
A phosphorylated glycoprotein that is produced by bone, is abundant in bone mineral matrix, and accelerates bone regeneration and remodeling. It is also produced in other tissues and plays a role in the progression of many diseases, including certain cancers.

osteopontin

(ŏs″tē-ō-pŏn′tĭn)
An extracellular matrix glycoprotein (approximate molecular weight 44 to 64 kD). It has been implicated in the pathophysiology of inflammatory, autoimmune, and malignant disorders as well as in wound repair.

osteopontin

a sialopontin found in cells in bone tissue but its function is not understood.
References in periodicals archive ?
Regulation of osteopontin gene expression during egg shell formation in the laying hen by mechanical strain.
Regulatory effects of interferon-b on osteopontin and interleukin-17 expression in multiple sclerosis.
Osteopontin as a potential diagnostic biomarker for ovarian cancer.
We hypothesized blocking of the bone differentiation pathway via siRNA against GNAS1 (siGNAS1) and the hypoxia pathway via siRNA against PHD2 (siPHD2) would affect MSC proliferation and expression of collagen, osteopontin, and alkaline phosphatase (ALP).
RT-PCR analysis showed that bone specific proteins including osteopontin and osteocalcin were expressed in the cells.
com)-- The second species-specific kit in a line of Osteopontin ELISAs is now available from ALPCO.
These cells secrete a protein called osteopontin that hooks the stem cells to the bone marrow.
Homocysteine attenuates the expression of osteocalcin but enhances osteopontin in MC3T3-E1 preosteoblastic cells.
In the case of a slip, trip, or fall, the force of the impact on a bone physically deforms a pair of joined proteins, osteopontin and osteocalcin, and results in the formation of nanoscale holes.
Regulation of adverse remodelling by osteopontin in a genetic heart failure model.
They reduced os teocalcin, increased osteopontin and decreased BMPs, accelerating bone loss.

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