osteopontin


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Related to osteopontin: Osteocalcin, Osteonectin

os·te·o·pon·tin

(os'tē-ō-pon'tin),
A secreted phosphoprotein, produced by many epithelial cell types, which is highly negatively charged and frequently associated with mineralization processes. It is found in plasma, urine, milk, and bile. Transformed cells express osteopontin in elevated levels.
Synonym(s): bone sialoprotein 1

osteopontin

(ŏs′tē-ō-pŏn′tn)
n.
A phosphorylated glycoprotein that is produced by bone, is abundant in bone mineral matrix, and accelerates bone regeneration and remodeling. It is also produced in other tissues and plays a role in the progression of many diseases, including certain cancers.

osteopontin

(ŏs″tē-ō-pŏn′tĭn)
An extracellular matrix glycoprotein (approximate molecular weight 44 to 64 kD). It has been implicated in the pathophysiology of inflammatory, autoimmune, and malignant disorders as well as in wound repair.

osteopontin

a sialopontin found in cells in bone tissue but its function is not understood.
References in periodicals archive ?
8] Osterix is located downstream of Runx2, and its main role is to increase the expression of osteopontin and ALP.
2015) Baseline osteopontin levels predict the clinical effectiveness of tocilizumab, but not infliximab in biologic-naive patients with rheumatoid arthritis: a single center prospective study at 1 year.
KEYWORDS: Osteopontin, Stathmin-1, Taxane resistance, Metastatic castrate-resistant prostate cancer, Survival.
49,50) An abundant expression of osteopontin in Langerhans cells from lesional tissue in PLCH has also been observed.
Imbalance of many molecular factors including bone morphogenic protein-2 (BMP-2), osteopontin, osteoprotegrin, parathyroid related protein (PTHrP), matrix-glaprotein and phosphate have been studied.
Abbreviations CaOx: Calcium oxalate EG: Ethylene glycol OS: Oxidative stress SD: Sprague-Dawley SOD: Superoxide dismutase ROS: Reactive oxygen species MDA: Malondialdehyde CAT: Catalase OPN: Osteopontin KIM-1: Kidney injury molecule-1 BUN: Blood urea nitrogen Cr: Serum creatinine.
Reifenrath, "Magnesium-based bone implants: immunohistochemical analysis of peri-implant osteogenesis by evaluation of osteopontin and osteocalcin expression," Journal of Biomedical Materials Research--Part A, vol.
Pradeep, "Gingival crevicular fluid osteopontin levels in periodontal health and disease," Journal of Periodontology, vol.
The osteoblast transcription factor Runx2 is expressed in mammary epithelial cells and mediates osteopontin expression.

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