In our experience the osteopetrotic
bones are hard and sclerotic, but fracture with minor trauma, so gentle handling of fracture fragments is required.
Previous studies have shown that Src-deficient mice exhibit an osteopetrotic
phenotype (Soriano et al.
mice (op/op), which lack MCSF-1, have been shown to harbor 24% fewer microglia in the cerebral cortex than wild-type controls; however, the microglial morphology was relatively normal .
1994) Cadmium-induced osteomalacic and osteopetrotic
lesions in overiectomized rats.
Progressive increase in bone mass and development of odontomas in aging osteopetrotic
14) Mice with increased expression of OPG are osteopetrotic
(23) while animals with deficiency of OPG present osteoporosis.
The hard osteopetrotic
bone caused several drill-bits to wear out before a drill duct for a 9 mm intramedullary nail was achieved (Fig.
Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic
Inhibition by dithionite and reactivation by iron of the tartrate-resistant acid phosphatase in bone of osteopetrotic
Effects of vitamin D binding protein-macrophage activating factor (DBP-MAF) infusion on bone resorption in two osteopetrotic
16, 2000), and the paper by Amling et al, "Progressive increase in bone mass and development of odontomas in aging osteopetrotic
c-src-deficient mice" (Bone 27(5), Nov.
conditions vary greatly in their presentation and severity, ranging from neonatal onset with life-threatening complications (classic or "malignant" ARO), to the incidental finding of osteopetrosis on radiographs (ADO) and mild form of autosomal recessive osteopetrosis (mild ARO/intermediate OP) a more uncommon form of the disease.