osteomalacia

osteomalacia /os·teo·ma·la·cia/ (os″te-o-mah-la´shah) inadequate or delayed mineralization of osteoid in mature cortical and spongy bone; it is the adult equivalent of rickets and accompanies that disorder in children.osteomala´cic

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hepatic osteomalacia  osteomalacia as a complication of cholestatic liver disease, which may lead to severe bone pain and multiple fractures.

oncogenic osteomalacia , tumor-induced osteomalacia osteomalacia occurring in association with mesenchymal neoplasms, which are usually benign.

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os·te·o·ma·la·cia (st--m-lsh)

n.

A bone disease characterized by bone demineralization due to deficiency or impaired metabolism of vitamin D or phosphates. Also called adult rickets, late rickets.

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Osteomalacia

Osteomalacia is a bone disease that occurs in adults and is caused by a prolonged period of vitamin D deficiency.

Mentioned in: Bone X Rays, Laxatives, Vitamin D Deficiency

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osteomalacia

[-məlā′shə]

Etymology: Gk, osteon + malakia, softening

an abnormal condition of lamellar bone, characterized by a loss of calcification of the matrix and resulting in softening of the bone. It is accompanied by weakness, fracture, pain, anorexia, and weight loss. The condition is the result of an inadequate amount of phosphorus and calcium available in the blood for mineralization of the bones. This deficiency may be caused by a diet lacking these minerals or vitamin D, by a lack of exposure to sunlight and hence an inability to synthesize vitamin D, or by a metabolic disorder causing malabsorption of minerals. Osteomalacia results from and also complicates many other diseases and conditions. Treatment usually includes administration of the necessary vitamins and minerals and therapy appropriate for the underlying disorder. Also called adult rickets. See also hyperparathyroidism, Paget's disease, rickets.

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osteomalacia (os´tēōmlā´shē, -sh),

n a systemic disorder of bone characterized by decreased mineralization of bone matrix possibly resulting from vitamin D deficiency, inadequate calcium in the diet, renal disease, and/or steatorrhea. Manifestations include incomplete fractures and gradual resorption of cortical and cancellous bone.

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osteomalacia

softening of the bones of adult animals, resulting from impaired mineralization, with excess accumulation of osteoid, caused by a nutritional deficiency of vitamin D or phosphorus. The clinical signs are those of a painful condition of the bones and joints, including stiff gait, lameness, restlessness while standing, cracking sounds in the joints while walking, an abnormal posture including an arched back. Affected animals are disinclined to move and lie down for long periods. Fractures and tendon ruptures occur frequently and pelvic deformity may cause dystocia. Called also stifsiekte, stiffs, creeps, peglegs, cripples, bog-lame, milk-leg, milk-lame.

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osteomalacia

Nutritional rickets A condition characterized by softened bones due to poor mineralization occurring in a background of vitamin D deficiency Clinical Weak, deformed, and deformable bone, which in children may be manifest by craniotabes, bowlegs, and knock knees, rachitic rosary, ↓ ventilation, often accompanied by pneumonia, muscular weakness, ↓ appetite, hypocalcemia Treatment Vitamin D. See Osteogenic osteomalacia, Rickets.