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osteoclastic

   Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia 0.01 sec.
osteoclastic
[-klas′tik]
1 pertaining to osteoclasts.
2 destructive to bone.


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Currently FDA-approved bisphosphonates, including Fosamax (alendronate), Actonel (risedronate), Didronel (etidronate), Boniva (ibandronate), and Reclast (Zometa) (zoledronate), are designed to strengthen bone by inhibiting normal osteoclastic bone resorbing activity, which slows the loss of bone mineral density (BMD), allowing the trabecular architecture to stabilize.
Bone turnover improved selectively in women >70 years old, as assessed by the dualenergy x-ray absorptiometry (DEXA) technique and the decrease of osteoclastic activity.
 
 
 
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