osteoclast-like giant cell


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osteoclast-like giant cell

A multinucleated giant cell with abundant eosinophilic, finely granular or homogeneous cytoplasm containing up to 100 uniform oval nuclei, each measuring 5–7 µm with scattered small nucleoli and peripheral chromatin.
 
DiffDx
Osteoclast-like giant cells are often scattered among plump spindled mononuclear cells and may occur in benign and malignant conditions—e.g., fibrous histiocytoma, Langerhan’s cell histiocytosis, in the mural nodules of mucin-producing ovarian and liver cancer, Hodgkin lymphoma, tumoural calcinosis.
References in periodicals archive ?
In Erdheim-Chester disease, the bone marrow is replaced by a proliferation of large, foamy histiocytes embedded in dense fibrous tissue with sparse inflammatory cells and multinucleated, osteoclast-like giant cells.
Primary lung tumors infiltrated by osteoclast-like giant cells.
Bronchogenic sarcomatoid squamous cell carcinoma with osteoclast-like giant cells.
A histologic hallmark of OF includes irregularly distributed woven and interconnecting lamellar bone with prominent osteoblastic rimming within a hypercellular spindle cell, fibroblast-like stroma admixed with variable numbers of randomly distributed osteoclast-like giant cells.
6] Classic microscopic features include proliferating spindle cells and osteoclast-like giant cells lining pseudovascular cavernous spaces; a fibromyxoid background substance with scattered chondroid and osteoid changes often may be recognized.
Giant cell tumor has multinucleated osteoclast-like giant cells, often displaying innumerable nuclei ([is greater than] 20 up to 100), and usually does not have the characteristic fibromyxoid milieu with chondroid or osteoid changes.
In contrast, ACE antigen was detected in a plasmalemmal distribution in all cases, was most prominent in histiocytes that lacked the karyomorphism of Langerhans cells, and was occasionally noted on osteoclast-like giant cells and endothelial cells.
4,10,11] The presence of variable numbers of multinucleated osteoclast-like giant cells, as a morphologic concomitant in these LCH lesions, supports such a pathogenic sequence.
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