osteitis deformans


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Related to osteitis deformans: osteogenesis imperfecta, Paget's disease, rickets, rheumatoid arthritis

osteitis

 [os″te-i´tis]
inflammation of bone, often with enlargement, tenderness, and a dull, aching pain.
alveolar osteitis dry socket.
condensing osteitis osteitis with hard deposits of earthy salts in affected bone.
osteitis defor´mans rarefying osteitis of unknown cause resulting in deformed bones of increased mass leading to bowing of the long bones and deformation of the flat bones. See also paget's disease.
osteitis fibro´sa cys´tica rarefying osteitis with fibrous degeneration and the formation of cysts and the presence of fibrous nodules on the affected bones, due to osteoclastic activity secondary to hyperparathyroidism. If a tumor of the parathyroid gland is the cause of the hyperparathyroidism, treatment includes removal of the tumor. When the disease is generalized, all the bones are affected (von recklinghausen's disease). Orthopedic surgery may be necessary to correct severe bone deformities.
osteitis fragi´litans osteogenesis imperfecta.
osteitis fungo´sa chronic osteitis in which the haversian canals are dilated and filled with granulation tissue.
rarefying osteitis a bone disease in which the inorganic matter is diminished and the hard bone becomes cancellated.

Pa·get dis·ease

(paj'ĕt), [MIM*602080, MIM*167300]
1. a generalized skeletal disease, frequently familial, of older people in which bone resorption and formation are both increased, leading to thickening and softening of bones (for example, the skull), and bending of weight-bearing bones; Synonym(s): osteitis deformans
2. a disease of elderly women, characterized by an infiltrated, somewhat eczematous lesion surrounding and involving the nipple and areola, and associated with subjacent intraductal cancer of the breast and infiltration of the lower epidermis by malignant cells;

osteitis deformans

Paget disease of bone type 2

A disorder of bone remodelling (OMIM:602080) that involves the axial skeleton, with lesions of the spine, pelvis and skull.
 
Molecular pathology
Caused by defects in TNFRSF11A, which encodes a member of the TNF receptor that is essential for RANKL-mediated osteoclastogenesis.

Pa·get dis·ease

(paj'ĕt di-zēz')
1. A generalized skeletal disease, frequently familial, of older people in which bone resorption and formation are both increased, leading to thickening and softening of bones (e.g., the skull), and bending of weight-bearing bones.
Synonym(s): osteitis deformans.
2. A disease of old women, characterized by an infiltrated, somewhat eczematous lesion surrounding and involving the nipple and areola, and associated with subjacent intraductal cancer of the breast and infiltration of the lower epidermis by malignant cells.

osteitis deformans

See PAGET'S DISEASE.

Pa·get dis·ease

(paj'ĕt di-zēz') [MIM*602080, 167300]
1. A generalized skeletal disease, frequently familial, of older people in which bone resorption and formation are both increased, leading to thickening and softening of bones (e.g., the skull), and bending of weight-bearing bones.
Synonym(s): osteitis deformans.
2. A disease of elderly women, characterized by an infiltrated, somewhat eczematous lesion surrounding and involving the nipple and areola, and associated with subjacent intraductal cancer of the breast and infiltration of the lower epidermis by malignant cells.

osteitis

inflammation of bone. The term is used to describe a number of conditions; for instance, advanced cases of brucellosis can lead to brucellar osteitis. See also osteomyelitis.

alveolar osteitis
necrosis of alveolar bone at the site of a tooth extraction. Called also dry socket.
osteitis deformans
osteitis causing deformity of bones.
osteitis fibrosa
osteitis fibrosa cystica
rarefying osteitis with fibrous degeneration and the formation of cysts and the presence of fibrous nodules on the affected bones, due to osteoclastic activity secondary to hyperparathyroidism. See also osteodystrophia fibrosa.
rarefying osteitis
a bone disease in which the inorganic matter is diminished and the hard bone becomes cancellated.
sclerosing osteitis
1. sclerosing nonsuppurative osteomyelitis.
2. condensing osteitis.