osmotoxicity

osmotoxicity

(ŏz″mō-tŏk′sĭs′ĭ-tē) [″ + ″]
The adverse effects of highly concentrated fluids on body structures. These effects are often observed when radiological contrast media with a dense concentration of solute are injected into the body during imaging procedures. Patients may experience a sense of warmth, have low or high blood pressures, or suffer adverse effects caused by cell membrane dysfunction, e.g., alterations in the flexibility of red blood cell membranes or in the permeability of the lungs to gas exchange.
References in periodicals archive ?
It has been presupposed that osmotoxicity is fundamental to CIN.
Proponents of iso-osmolar contrast media consider the blood isotonicity and the resulting lack of osmotoxicity of these to be the reason for the better tolerance demonstrated in a number of clinical trials, where the protection of impaired kidneys is concerned.