ortholog


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Related to ortholog: paralog

ortholog

or

orthologue

(ôr′thə-lôg′, -lŏg′)
n.
A homologous gene that is related to those in different organisms by descent from the DNA of a common ancestor and that may or may not have the same function.

or·thol′o·gous (-thŏl′ə-gəs) adj.

ortholog

(ŏr′thō-lŏg″) [″ + (ana)log(ue)]
A gene that is shared by members of different species.
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References in periodicals archive ?
Ganapathy and MCG researchers have identified orthologs of this longevity gene in humans, mice, rats and zebrafish as well as in the nematode worm C.
22,30,44) Otx is not activated at the 16-cell stage, because an additional activator is required for its expression: the secreted signaling molecule Fgf9/ 16/20, the sole ortholog of vertebrate FGF9, FGF16 and FGF20, which is expressed in the vegetal hemisphere from the 16-cell stage.
For example, although the estrogen receptor (ER) is well conserved across vertebrate species (Baker 2011), a functional ortholog has not been found in invertebrate species (Baker et al.
Other studies have suggested that the zebrafish Aqp0b ortholog of mammalian AQP0, which also functions as a cellular adhesion molecule (Costello et al.
Data are transferred between organisms by using the InParanoid Eukaryotic Ortholog Groups' database (InParanoid 2009; O'Brien et al.
japonica were assessed using a publicly available ortholog sequence from the latter (Genbank accession no.
An excellent chapter on the Fet3 protein, which is the yeast ortholog of ceruloplasmin is, however, included.
Pre-computed human-mouse ortholog pairs displayed with synteny information and neighboring genes.
Interestingly, rapid transport of an AQP8 ortholog into the mitochondria of activated spermatozoa was also noted recently in the Atlantic salmon Salmo salar (Chauvigne et al.
The human ortholog of the yeast MTQ2 is N-6 adenine-specific DNA methyltransferase 1 (N6AMT1), encoding a putative methyltransferase.
These findings suggest that the homolog or ortholog of these fish aqps might have given rise to tetrapod aqp2, aqp5, and aqp6 via gene duplication (Konno et al.