There was marked orthokeratosis
, focal parakeratosis, papillomatosis, acanthosis and follicular plugging with focal hypergranulosis.
A skin biopsy demonstrated psoriasiform dermatitis with alternating areas of orthokeratosis
and parakeratosis (the presence of keratinocyte nuclei within the stratum corneum where nuclei typically aren't found).
Punch biopsy was taken from back and histopathological examination (HPE) of hematoxylin and eosin-stained (HandE) section revealed basket weave orthokeratosis
with a column of parakeratotic cells, the cornoid lamella, characteristic of porokeratosis.
Skin biopsy from the abdominal lesion showed laminated orthokeratosis
, a normal granular layer, and a thickened granular layer in some areas.
Excluding molluscum and verruca, there were 2 other biopsy specimens with an infectious etiology, one of which was dermatophytosis interpreted as "basketweave orthokeratosis
with parakeratosis and superficial perivascular lymphocytic infiltrate" and phaeohyphomycosis called SCC.
There was mild orthokeratosis
and a few remaining hair follicles.
18 Changes in epithelium observed in the patients with OSF shows mostly epithelial atrophy, or epithelial hyperplasia, keratosis with either hyper orthokeratosis
or hyper parakeratosis, pyknosis in basal layer nuclei, lack of glycogen in severe Grade III scenarios, intercellular edema, hyalinization occurring close to epithelium and collagen with diverse thickness19 vacuolization of prickle-cell layer, amplified mitotic activity, Increased levels of pro-inflammatory cytokines and reduced antifibrotic interferon have also been demonstrated in patients with OSF and atypical epithelium changes20 with moderate epithelial hyperplasia eventually resulting in squamous cell carcinoma.
Skin biopsy revealed epidermal orthokeratosis
and dermis with perivascular and periadnexal infiltrate composed by lymphocytes, neutrophils and plasma cells.
Histopathologic features are diverse degrees of orthokeratosis
and parakeratosis besides thickness of spinous layer.
Skin histopathology revealed markedly thinned out epidermis, exhibiting orthokeratosis
and complete flattening of rete pegs.
Microscopically, the surface of the lesion displays hyperkeratosis and orthokeratosis
Histopathological studies showed inhibition in cellular infiltration and reduction of synovial hyperplasia and synovitis, whereas in the second test, histopathological and ultrastructural studies showed that topical application of FAM induced orthokeratosis
with the presence of keratohyalin granules in the previously parakeratotic adult mouse tail, and without effects on epidermal thickness.