orphan nuclear receptor

orphan nuclear receptor

member of the family of nuclear hormone receptor that have no known ligand. Some (for example, steroidogenic factor 1, DAX-1) have been associated with human diseases.
References in periodicals archive ?
Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain.
The keynote lecture provides an introduction to the nuclear receptor superfamily and the remaining contributions discuss such topics as metabolic control by LXR receptors, regulation of cardiac energetic by the orphan nuclear receptors ERR-alpha and ERR-gamma, FXR and bile acids as critical modulators of metabolisms, the role of PPARs in human prediabetes, the role of the intestine in reverse cholesterol transport, NR4A nuclear receptors in the vessel wall, cholesterol as a novel target in the treatment of Alzheimer's disease, PPAR-gamma mediated effects in central nervous system disorders, and the role of the orphan nuclear receptor rev-erb-alpha in the molecular biology of circadian rhythms and cardiometabolic disease.
The 5-LOX gene has been shown to carry a response element for the orphan nuclear receptor RORalpha (for its RORalpha1 isoform in particular) in its promoter region.
says that SRC-2 works with an orphan nuclear receptor ROR alpha to affect the activity of the sugar-converting enzyme, glucose-6-phosphatase in the liver.
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway.
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.
Control of the steroidogenic metabolic pathway is regulated partly by P450 cytochrome hydroxylases, and the expression of many of these enzymes is controlled by the orphan nuclear receptor, steroidogenic factor-1 (SF-1).