It's likely that some orphan gene clusters produce enzymes that could make new antibiotics.
Working with scientists at Scripps Institution of Oceanography at the University of California-San Diego; Oregon State University; and Northland College, in Ashland, Wisconsin, Loper investigated a new method for determining the products of orphan gene clusters.
To do this, the scientists label the chemical building blocks with isotopes and then place the labeled molecules in a culture of the Pseudomonas bacterium that has the orphan gene cluster.
A joint project conducted by Loper and Harry Gross, at the University of Bonn, Germany, demonstrated that a second Pseudomonas orphan gene cluster codes for biosynthesis of compounds related to rhizoxin--an antibiotic and potential antitumor substance.
AIPGENE is a European Commission Framework Programme 7-funded consortium (Grant Agreement number 261506) which was put together with the aim to develop the orphan gene
therapy drug AAV5-AAT-PBGD (AMT-021) for the treatment of Acute Intermittent porphyria (AIP).
has discovered the function of five orphan gene
During early regenerative growth, genes called orphan genes are active, Anoop Kumar of University College London and colleagues report October 26 in Nature Communications.
It becomes tempting to think that amniotes are hiding a latent capacity to perform complex regeneration, and the correlation with a potential molecular mechanism, orphan genes, points to a good place to start.
Their writing greatly expands the case Meyer argues for in Darwin's Doubt, ranging across subjects like orphan genes
, cladistics, the famous "small shelly fossils," protein evolution, the length of the Cambrian explosion, the God-of-the-Gaps objection to ID, and more.
We will test hypotheses about: (1) the primary drivers of gene content evolution, (2) the repeatability of patterns in gene loss and retention after WGD, and (3) the early evolution of orphan genes
These so-called orphan genes
could have a tremendous amount to do with diversification of animal lineages, but people just pooh-pooh these differences and focus on the things that are shared," he says.