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orotic aciduria |
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orotic aciduria, a rare autosomal-recessive inherited disorder of pyrimidine metabolism. It includes signs and symptoms of macrocytic hypochromic anemia with megaloblastic changes in bone marrow, leukopenia, retarded growth, and urinary excretion of large amounts of orotic acid. aciduria the excretion of acid in the urine. See also specific forms, such as aminoaciduria, orotic aciduria. orotic aciduria appearance of orotic acid, an intermediate of pyrimidine synthesis, in the urine due to a lack of orotate phosphoribosyltransferase activity. paradoxical aciduria occurs when a metabolic alkalosis caused by severe vomiting or pooling of gastric secretions in the abomasum leads to renal bicarbonate reabsorption and sodium-hydrogen exchange with the inappropriate production of acid urine. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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