organophosphorus compound


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organophosphorus compound

an organic ester of phosphoric or thiophosphoric acid; such compounds are powerful acetylcholinesterase inhibitors and are used as insecticides and anthelmintics. They are also used industrially as fire-resistant hydraulic fluids, coolants and lubricants and animals may be accidentally exposed to them. All organophosphorus compounds are poisonous, even those used pharmacologically, if given in large enough doses or in particular circumstances.

organophosphorus compound-induced delayed neurotoxicity
paralysis occurring 3 weeks after exposure to organophosphorus compounds, especially industrial organophosphates; the degree of paralysis varies from weakness appearing as knuckling of the fetlocks to complete flaccid paralysis.
industrial organophosphorus compound
see organophosphorus compound (above). Includes aryl-, cresyl-, and tolyl- phosphates used commercially as flame retardants and wood preservatives. Access to the substances or, more commonly, premises contaminated by them may cause poisoning, especially delayed neurotoxicity.
organophosphorus compound insecticide
includes a very wide range of contact insecticides, systemic insecticides for animals and plants; all have significant toxic potential.
organophosphorus compound poisoning
signs of poisoning differ between the species. (1) Cattle show salivation and diarrhea, tremor and stiffness and a pathognomonic constriction of the pupil. (2) Sheep and pigs show predominantly nervous signs. In sheep ataxia, posterior paralysis and spinal cord degeneration are indicators. In pigs nystagmus, tremor, recumbency, posterior paralysis and drowsiness occur. (3) Horses show abdominal pain, diarrhea, ataxia, dyspnea and in foals acute bilateral laryngeal paralysis. (4) Dogs and cats show salivation, tremors and muscle fasciculations, vomiting and diarrhea, constriction of the pupils, ataxia and convulsions.
References in periodicals archive ?
3) Organophosphorus compound poisonings are found to be a leading cause of death in agricultural countries globally.
Poisoning with organophosphorus compound (OPC): Mythology vs.
121 patients were studied and found that the levels of serum LDH and creatine kinase levels were markedly elevated among poisoning cases indicating muscular impairment due to organophosphorus compound toxicity.
Organophosphorus compounds are used globally for pest control over 100 years.
So this serious condition needs rapid diagnosis, early and effective treatment and up gradation of the primary health centre facilities to render immediate management of Organophosphorus compound poisoning, this study also highlighted that early admission to hospital decreases mortality.
INTRODUCTION: Organophosphorus compound poisoning is a global problem and is a familiar medical emergency which is associated with high rate of mortality if not diagnosed and treated early.
Inclusion Criteria: A history of exposure to organophosphorus compound within previous 24 hours with characteristic clinical manifestations of organophosphorus compound poisoning.
Quader M, Rahman MH, Kamal M, Ahmed AU, Saha SK--Post Mortem outcome of organophosphorus compound poisoning cases at Mymen singh Medical College.
Suspected patients of organophosphorus poisoning with a particular smell of organophosphorus compound on naso-gastric suction, or insecticide containers brought by the relatives with strong suspicion were included in the study.
Acute Organophosphorus compound poisoning is an important indication for emergency admission in most hospitals throughout India.
FASCICULATIONS NUMBER OF NUMBERS PERCENTAGE SCORING PATIENTS VENTILATED 0 33 0 0 1-3 05 03 60% 4-6 12 12 100% TABLE 8: TYPE OF ORGANOPHOSPHORUS COMPOUND & ITS RELATIONSHIP TO NEED FOR VENTILATOR SUPPORT NAME OF COMPOUND NUMBEROF NUMBERS PERCENTAGE PATIENTS REQUIRING REQUIRING VENTILATION VENTILATION Methyl parathion 25 (50%) 15 60% (metacid) Fenithorothion Dimethoate 6 (12%) 4 66% Miscellaneous Monocrotophos 7 (14%) 2 28% Dichlorovas, Diazinon TABLE 9: ASSOCIATION OF GLASSGOW COMA SCALE SCORING AND NEED FOR VENTILATOR SUPPORT.

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