likely represent a small fraction of total arsenic exposure because consumption of seafood, a primary source of organic arsenic exposure, is low in this population (62% of mothers reported never consuming a 3- to 5-oz serving of fish during pregnancy).
According to Chris Le, a professor in the University of Alberta's Department of Laboratory Medicine and Pathology, the dividing line between toxic and non-toxic arsenic is often presented as non-organic versus organoarsenicals
Of the inorganic forms, arsenite (trivalent) and arsenate (pentavalent) are the two most prevalent and potential dangerous forms, while organic form of organoarsenicals
is of importance (Dopp et al.
However, there are no reports of acute toxicities in man resulting from the consumption of organoarsenicals
It has been reported that numerous Organoarsenicals
, the most importantly, arsenocholine, arsenobetaine, monomethylarsonate and dimethylarsinate, rather than arsenate and arsenite .
Organic arsenic compounds (such arsenobetaine found in mushrooms, fish, and shellfish) generally are less toxic, although organoarsenicals
have been used as chemical warfare agents (e.
10:45 BIOTRANSFORMATION STUDIES OF ORGANOARSENICALS
, Abe A.
The phenol extraction procedure has been used previously with good results to separate naturally occurring organoarsenicals
from inorganic salts and highly polar organic compounds present in urine (7).
Therefore, failure to distinguish organoarsenicals
from inorganic arsenic and metabolites of inorganic arsenic in urine may result in misclassification of exposure to the most toxicologically relevant forms of arsenic, which in turn may lead to mischaracterization of the association between urinary arsenic and diabetes.
The biotransformation studies of "hidden" organoarsenicals
The rest is present as organoarsenicals
, both water soluble and lipid soluble.
, such as arsenocholine, tetramethylarsonium ion, trimethylarsine oxide, and trimethylarsine, have also been reported to be present in some seafoods at much lower concentations than arsenobetaine and arsenosugars .