Because iodine uptake is low in this type of AIT, targeting the organification
process with a thionamide would not be expected to have a significant effect.
In the present study, screening by single-strand conformational polymorphism (SSCP) and direct sequencing analysis of the DUOX2 gene revealed 3 previously unreported mutations and 1 previously reported mutation in 2 unrelated families with congenital goiter and iodide organification
defect, constituting 2 compound heterozygous mutations (p.
Pendred syndrome maps to chromosome 7q21-34 and is caused by an intrinsic defect in thyroid iodine organification
Evidence of defective cellular oxidation and organification
of iodide in a female with fybromyalgia and chronic fatigue.
Mutations in the pendrin protein result in defects in iodide transport into the follicular lumen and impaired iodide organification
The inefficient iodine retention mechanism could be due to either an inefficient cellular iodine transport system or to an inefficient oxidation and organification
of the intracellular iodide, or possibly both.
The peripheral iodide enters the thyrocyte via the symporter in the basal membrane and crosses the thyrocyte as iodide to exit the thyrocyte via the apical membrane transporter just prior to oxidation and organification
Since the above enzymes are involved in the production of hydrogen peroxide by the thyroid gland, and hydrogen peroxide is the oxidant used by TPO to oxidize symported iodide, (10) mild bromism may be a factor in some forms of hypothyroidism caused by decreased oxidation and organification
of intracellular iodide.
We review the literature to identify genetic defects involved in the iodination process of the thyroid hormone synthesis, particularly defects in iodide transport from circulation into the thyroid cell, defects in iodide transport from the thyroid cell to the follicular lumen (Pendred syndrome), and defects of iodide organification
More than 50 years after the Wolff-Chaikoff forgery, it is still quoted in iodophobic publications: "Acute excess iodine ingestion has long been known to result in a transient decrease in iodine organification
, termed the acute Wolff-Chaikoff effect.
Although PTU reduces thyroid hormone production by inhibiting thyroglobulin organification
in the thyroid and inhibiting the peripheral conversion of [T.
Bromide and thiocyanate not only attach to the halide binding site but are also transported inside the target cells, causing further damage by preventing oxidation and organification