falciparum infection has been attributed to the impaired opsonic
phagocytic clearance of malaria parasites, especially in multigravid women (33,46), and reduced levels of specific antibodies associated with protection against malaria in pregnancy.
role of tunicate IL-1-like molecules reported by Kelly et at.
In cirrhotic patients, the bactericidal and opsonic
activity of the ascitic fluid is lower than that observed in noncirrhotic ascites or in normal peritoneal exudate (3,12,13) Recent investigations have shown that cirrhotic patients with low ascitic fluid C3 and low ascitic fluid total protein are more predisposed to SBP.
involvement in phagocytosis by mollusk hemocytes.
A transient bacteraemia that infects the pleural space could be the underlying pathogenic mechanism apart from the impaired opsonic
activity of the pleural fluid.
Previous investigators have also reported that the N-terminal regions of M proteins possess functional domains in addition to opsonic
epitopes that might constrain the amount of variability within an M type (30-33).
Further studies have shown that the particular opsonic
defect predisposes to respiratory infection, diarrhoea, atopy and failure to thrive during infancy (28-31).
14) Patients with cirrhosis of the liver have depressed reticuloendothelial activity, decreased ascitic-fluid opsonic
activity bowel wall edema, and bacterial colonization of the small bowel (15) moreover, there is decreased clearance of bacteria from the blood stream in these patients.
Tripep has out licensed the RAS[R] technology to Opsonic
The classical complement pathway and heat-stable opsonins are required for maximal opsonic
activity against the major serotypes of CBS.
STOCKHOLM, Sweden -- Tripep (STO:TPEP) and the German biotech company Cosmix AG have both licensed their respective technologies (RAS and mRNA Display Library) to a newly formed US company named Opsonic
Dale reported that rabbits given the prototypic group A streptococcus vaccine developed high levels of opsonic
(protective) antibodies against six targeted strains of group A streptococcus.