Oprelvekin | definition of oprelvekin by Medical dictionary
Also found in: Wikipedia
oprelvekin /oprel·ve·kin/ (o-prel´vĕ-kin″) recombinant interleukin-11, used as a hematopoietic stimulator to prevent thrombocytopenia following myelosuppressive chemotherapy.
recombinant interleukin-11, used as a stimulator of hematopoiesis to prevent thrombocytopenia after myelosuppressive chemotherapy.
IL11 A gene on chromosome 19q13.3-q13.4 that encodes interleukin-11, a member of the gp130 family of cytokines, which drive the assembly of multi-subunit receptor complexes, all of which contain at least one molecule of the transmembrane signalling receptor IL6ST. IL11 directly stimulates the proliferation of haematopoietic stem cells and megakaryocyte progenitor cells, and it induces megakaryocyte maturation resulting in increased platelet production.
References in periodicals archive
The major hurdle with the use of thrombopoietin agonist and oprelvekin
was cost, romiplostim ($1400), eltrombopag ($2000), and oprelvekin
($2366) for the management of CIT per week, respectively.
(Neumega[R]), also known as interleukin 11, is a growth factor that is used to prevent thrombocytopenia following chemotherapy infusion.