opioid receptors


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Related to opioid receptors: Opioid Analgesics

Opioid receptors

Receptors located in the brain and various organs that bind opiates or opioid substances.
Mentioned in: Methadone

opioid receptors

specific cell surface receptors within the central and peripheral nervous system, which combine with naturally occurring opioid compounds (e.g. endorphins) to reduce pain and increase euphoria

opioid receptors,

n.pl any of the several receptors to which opiates bind. Classified into three groups delta, kappa, and mu based on the specific substances they bind and the resulting physiologic effects.

opioid

1. any synthetic narcotic that has opiate-like activities but is not derived from opium.
2. denoting naturally occurring peptides, e.g. enkephalins, that exert opiate-like effects by interacting with opiate receptors of cell membranes.

endogenous opioid
opioid receptors
specific receptor sites for opioids, named for the drugs which have a high binding affinity for them. The main ones are mu (morphine), kappa (opioid agonist-antagonists such as pentazocine) and delta (enkephalin endogenous opioids). Subtypes exist and others, such as sigma and epsilon, have been identified.
References in periodicals archive ?
In a test tube, the scientists melded the light-sensing protein rhodopsin to key parts of opioid receptors to activate receptor pathways using light.
Additional pipeline candidates include the backup development candidate for ADL5945, ADL7445, and a group of centrally-acting mu opioid receptor (CAMOR) antagonists with potential applications as an adjuvant to l-DOPA therapy for Parkinson's disease.
Salvinorin A, the most potent naturally occurring hallucinogen, is unusual in that it interacts with only one receptor in the human brain - the kappa opioid receptor (KOR).
And opioid receptors are the primary targets of the brain's reward system.
The FDA convened a meeting of the AADPAC to review the class of peripherally acting opioid receptor antagonists on June 11-12, 2014.
The study further suggests that kappa-mu opioid receptor heterodimers could function as a molecular switch that shifts the action of kappa-opioid receptors and endogenous chemicals that act on them from pain promoting to pain alleviating.
These growth differences disappear by21 days after birth, an observation consistent with other studies showing that opioid receptors in certain areas of the brain disappear as the animal matures.
When the opioids bind to certain opioid receptors in the gastrointestinal (GI) tract, constipation may occur.
Cara Therapeutics is a privately-held clinical-stage biopharmaceutical company focused on developing and commercializing new chemical entities designed to alleviate pain by selectively targeting kappa opioid receptors.
Study author Traci Ann Czyzyk-Morgan said that "the data presented here support the hypothesis that overactivation of kappa opioid receptors contribute to the development of obesity specifically during prolonged consumption of high-fat, calorically dense diets.
There are three major classes of opioid receptors - mu, kappa and delta.
Cara Therapeutics is a privately held clinical-stage biopharmaceutical company focused on developing and commercializing new chemical entities designed to alleviate pain by selectively targeting kappa opioid receptors.