opiate receptor


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opiate receptor

Etymology: Gk, opion, poppy juice; L, recipere, to receive
transmembrane proteins that bind to endogenous opioid neuropeptides and exogenous morphine and similar natural or synthetic compounds. The three major classes of these receptors are designated mu, kappa, and delta. Morphine preferentially stimulates mu receptors to produce analgesia, euphoria, respiratory depression, constipation, and pinpoint pupils. Some other drugs (e.g., butorphanol) can selectively block mu receptors while stimulating kappa receptors; this provides moderate to high pain relief with low abuse potential. Stimulation of delta receptors can also contribute to analgesia. The receptors are found in high concentrations in the dorsal horn of the spinal cord and in the brain regions involved with pain modulation or pain transmission. Endogenous agonists at these receptors include endorphins, enkephalins, and dynorphins.

opiate receptor

A specific site on a cell surface that interacts in a highly selective fashion with opiate drugs. These receptors mediate the major known pharmacological actions and side effects of opiates and the functions of the endogenous opiate-like substances (endorphins and enkephalins).
See also: receptor
References in periodicals archive ?
Buprenorphine is a partial opiate agonist at the mu receptor and an opiate antagonist at the kappa opiate receptor.
Effects of ethanol, temperature, and endogenous regulatory factors on the characteristics of striatal opiate receptors.
Wang said this is the first time black cohosh has been linked to the activity of the opiate receptors.
These receptors are known as opiate receptors, and there are three different subtypes designated the w, 6, and K receptors (Connor and Christie 1999).
Kieffer of the Ecole Superieure de Biotechnologie in Strasbourg, France, and her co-workers describe an opiate receptor that looks remarkably similar to the one the U.
As a private company they have developed a substantial knowledge of the chemistry and pharmacology of the delta receptor, including a library of approximately 1,000 compounds that demonstrate specific opiate receptor activity.
Bicifadine is not a narcotic and, in preclinical studies, it has been shown not to act at any opiate receptor.
Bicifadine has been shown not to act at any opiate receptor and therefore is not a narcotic.
The program is the only one in the world that concentrates on not stimulating the opiate receptors or even suppressing them naturally through specially designed menus.
The action of these medications includes binding to opiate receptors and changing the perception of and response to painful stimuli while producing central nervous system depression that is generalized (Florence & Palmer, 2003).
Suboxone contains a partial opiate agonist, which attaches to the opiate receptors in the brain, minimizing cravings without causing a high.
He explained that naloxone travels to the brain, where it works to push opiates off of opiate receptors.