ondansetron


Also found in: Dictionary, Thesaurus, Wikipedia.
Related to ondansetron: ondansetron HCl

antiemetic

 [an″te-e-met´ik]
1. useful in the treatment of vomiting.
2. an agent that relieves vomiting.

ondansetron

/on·dan·se·tron/ (on-dan´sĕ-tron) an antiemetic used as the hydrochloride salt, in conjunction with cancer chemotherapy, radiotherapy, or after surgery.

ondansetron

(ŏn-dăn′sĭ-trŏn′)
n.
A selective serotonin receptor antagonist, C18H19N3O, used in its hydrochloride form to prevent nausea and vomiting, especially when occurring postoperatively or as a result of chemotherapy or radiotherapy.

ondansetron

Oncology A selective serotonin S3 receptor antagonist used to ameliorate chemotherapy-induced N&V. See Chemotherapy-induced emesis.

ondansetron

A serotonin antagonist drug used to relieve nausea and vomiting caused by anticancer chemotherapy and radiotherapy and to prevent sickness after surgery. A brand name is Zofran.

ondansetron

a serotonergic antagonist, used as an antiemetic in chemotherapy.
References in periodicals archive ?
The study compared pregnancy outcomes among almost 2,000 women exposed to ondansetron in pregnancy and women not exposed to the drug between 2004 and 2011.
In the current study, Professor Johnson and his colleagues extended their prior work by analyzing variants of serotonin receptor genes, collectively designated as HTR3, among nearly 300 alcohol-dependent individuals who were participating in a clinical trial of ondansetron.
The seven patients who responded to subsequent ondansetron therapy were significantly more likely than nonresponders to have high scores in both of these areas.
The children were randomly assigned to receive either ondansetron or placebo in combination with caudal anaesthesia.
People with this biomarker have a statistically important response, while those studied that do not have this specific genotype did not respond to ondansetron.
Ondansetron 8 mg or granisetron 3 mg were given on Day 1 and Day 2 or palonosetron 0.
In 11 included studies, seven different antiemetics were evaluated, and children who received ondansetron were less likely to have on-going vomiting, be prescribed intravenous feeding, or be admitted to hospital from the emergency department.
A third trial conducted by Aapro and colleagues (6) evaluated the efficacy of palonosetron and ondansetron combined with a corticosteroid prior to HEC.
Conclusion: Patients administered low-dose granisetron experienced similar rates of PONV compared to ondansetron and dolestron for the prevention of PONV.
At two hours, 77% of acupoint patients had no nausea, vomiting or need for anti-emetic rescue, compared to 64% and 42% for the ondansetron and placebo groups, respectively.
Ondansetron hydrochloride belongs to a class of drugs known as 5HT3 antagonists that are widely used to prevent chemotherapy-induced nausea and vomiting.