on-off phenomenon ( n ôf)n. A state in the treatment of Parkinson's disease with dopa in which the individual exhibits a rapid fluctuation of akinetic and choreoathetotic movements. |
on-off phenomenon
Neurology An ↑ refractoriness to l-dopa's ability to control the smooth skeletal muscle movement in Parkinson's disease, where periods of excess abnormal movements–'on,' alternate with
periods of prolonged immobility or freezing–'off'; 'on-off' also refers to the waxing and waning of parkinsonism itself. See Parkinson's disease.
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