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on-off phenomenon

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on-off phenomenon (nôf)
n.
A state in the treatment of Parkinson's disease with dopa in which the individual exhibits a rapid fluctuation of akinetic and choreoathetotic movements.

on-off phenomenon
Neurology An ↑ refractoriness to l-dopa's ability to control the smooth skeletal muscle movement in Parkinson's disease, where periods of excess abnormal movements–'on,' alternate with periods of prolonged immobility or freezing–'off'; 'on-off' also refers to the waxing and waning of parkinsonism itself. See Parkinson's disease.


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20) The goal of DBS is to control symptoms and improve problems such as the on-off phenomenon and dyskinesias.
A partial explanation is that persons with Parkinson's suffer from an on-off phenomenon.
 
 
 
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