olsalazine sodium


Also found in: Dictionary.
Related to olsalazine sodium: Dipentum

olsalazine sodium

Dipentum

Pharmacologic class: Salicylate

Therapeutic class: Anti-inflammatory

Pregnancy risk category C

Action

Unknown. Converts to active form, mesalamine, which blocks cyclooxygenase and inhibits prostaglandin production in colon.

Availability

Capsules: 250 mg

Indications and dosages

Ulcerative colitis in patients who can't tolerate sulfasalazine

Adults: 500 mg P.O. b.i.d.

Contraindications

• Hypersensitivity to drug or other salicylates

Precautions

Use cautiously in:
• hepatic or renal impairment, severe allergy, bronchial asthma
• pregnant or breastfeeding patients
• children younger than age 14.

Administration

• Give with meals to reduce GI irritation.

Adverse reactions

CNS: headache, fatigue, depression, vertigo

GI: nausea, vomiting, diarrhea, abdominal pain, cramps, dyspepsia, bloating, stomatitis

Musculoskeletal: joint pain

Respiratory: upper respiratory infection

Skin: rash, itching

Interactions

Drug-drug.Anticoagulants, coumarin derivatives: prolonged prothrombin time, increased International Normalized Ratio

Drug-food.Any food: decreased GI irritation

Patient monitoring

• Monitor neurologic status. Stay alert for depression.
• Assess GI symptoms. Encourage adequate fluid intake to avoid dehydration.
• Monitor urinalysis, blood urea nitrogen, and creatinine in patients with renal impairment.

Patient teaching

• Instruct patient to take with food and to continue taking drug even after symptoms improve.
• Tell patient to eat appropriate foods in small, frequent servings to minimize GI upset.
• Advise patient to contact prescriber if symptoms worsen or don't improve after 1 to 2 months of therapy.
• Tell patient he may require periodic proctoscopy and sigmoidoscopy to determine response to drug.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects mood and wakefulness.
• As appropriate, review all significant adverse reactions and interactions, especially those related to the drugs and foods mentioned above.

olsalazine sodium (olsal´əzēn),

n brand name: Dipentum;
drug class: antiinflammatory, salicylate derivative;
action: bioconverted to 5-amino-salicylic acid, which decreases inflammation in the colon;
uses: maintenance of remission of ulcerative colitis in patients intolerant to sulfasalazine.
Mentioned in ?
References in classic literature ?
Phunky should have professed to have forgotten all about the merits of the case; but as he had read such papers as had been laid before him in the course of the action, and had thought of nothing else, waking or sleeping, throughout the two months during which he had been retained as Mr.
Phunky would not hear of passing through any door until Mr.