olsalazine sodium

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Related to olsalazine sodium: Dipentum

olsalazine sodium


Pharmacologic class: Salicylate

Therapeutic class: Anti-inflammatory

Pregnancy risk category C


Unknown. Converts to active form, mesalamine, which blocks cyclooxygenase and inhibits prostaglandin production in colon.


Capsules: 250 mg

Indications and dosages

Ulcerative colitis in patients who can't tolerate sulfasalazine

Adults: 500 mg P.O. b.i.d.


• Hypersensitivity to drug or other salicylates


Use cautiously in:
• hepatic or renal impairment, severe allergy, bronchial asthma
• pregnant or breastfeeding patients
• children younger than age 14.


• Give with meals to reduce GI irritation.

Adverse reactions

CNS: headache, fatigue, depression, vertigo

GI: nausea, vomiting, diarrhea, abdominal pain, cramps, dyspepsia, bloating, stomatitis

Musculoskeletal: joint pain

Respiratory: upper respiratory infection

Skin: rash, itching


Drug-drug.Anticoagulants, coumarin derivatives: prolonged prothrombin time, increased International Normalized Ratio

Drug-food.Any food: decreased GI irritation

Patient monitoring

• Monitor neurologic status. Stay alert for depression.
• Assess GI symptoms. Encourage adequate fluid intake to avoid dehydration.
• Monitor urinalysis, blood urea nitrogen, and creatinine in patients with renal impairment.

Patient teaching

• Instruct patient to take with food and to continue taking drug even after symptoms improve.
• Tell patient to eat appropriate foods in small, frequent servings to minimize GI upset.
• Advise patient to contact prescriber if symptoms worsen or don't improve after 1 to 2 months of therapy.
• Tell patient he may require periodic proctoscopy and sigmoidoscopy to determine response to drug.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects mood and wakefulness.
• As appropriate, review all significant adverse reactions and interactions, especially those related to the drugs and foods mentioned above.

olsalazine sodium (olsal´əzēn),

n brand name: Dipentum;
drug class: antiinflammatory, salicylate derivative;
action: bioconverted to 5-amino-salicylic acid, which decreases inflammation in the colon;
uses: maintenance of remission of ulcerative colitis in patients intolerant to sulfasalazine.
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