Furthermore, symmetric signal abnormalities of bilateral MCPs might also be apparent in other clinical conditions including Wilson disease, hepatic encephalopathy, extrapontine myelinolysis, acute disseminated encephalomyelitis, leukodystrophy, olivopontocerebellar
atrophy, spinocerebellar degeneration, toluene abuse, adrenoleukodystrophy, alcoholic liver disease, hypoglycemic coma, and progressive multifocal leukoencephalopathy.
Multiple system atrophy (MSA) is an adult onset, progressive, idiopathic neurodegenerative disease that involves, to varying degree, the basal ganglia, olivopontocerebellar
complex and autonomic system.
Matsushita, "The distribution and dynamic density of oligodendroglial cytoplasmic inclusions (GCIs) in multiple system atrophy: a correlation between the density of GCIs and the degree of involvement of striatonigral and olivopontocerebellar
systems," Acta Neuropathologica, vol.
Definite MSA requires "neuropathological findings of widespread and abundant CNS alpha-synuclein-positive glial cytoplasmic inclusions," along with "neurodegenerative changes in striatonigral or olivopontocerebellar
structures" at autopsy.
In the CBD variant associated with olivopontocerebellar
atrophy, the pons and cerebellum are markedly atrophied.
5) In a patient with MSA where a combination of olivopontocerebellar
atrophy and striato-nigral degeneration was present, the typical impairments of eye movement characteristic of PD were evident, viz.
It is seen with increasing prevalence in patients with Parkinson's Disease (PD), multiple system atrophy (MSA), diffuse Lewy-Body disease with dementia (DLBD), corticobasal degeneration, olivopontocerebellar
atrophy, and progressive supranuclear palsy (PSP).
MSA was originally divided into Shy-Drager syndrome, striatonigral degeneration, and olivopontocerebellar
atrophy, but this distinction is no longer made.
Urine vapor pattern for olivopontocerebellar
The other two are striatonigral degeneration and olivopontocerebellar
Their laboratory studies, using mice, suggest that genes involved in iron metabolism, or lack thereof, may be the cause of Parkinson's and other diseases in which excessive brain iron has been noted, such as Friedrich's Ataxia, Hallervorden-Spatz disease, and multiple system atrophy (formerly known as olivopontocerebellar
Primary neurologic or neuromuscular pathology occasionally results in OSA; such pathologies include Chiari malformation, syringomyelobulbia, cerebral palsy, myotonic dystrophy, Shy-Drager syndrome, acquired nonprogressive dysautonomia, olivopontocerebellar
degeneration, spinal cord injury, and bulbar stroke.