who met any two of the three criteria after exclusion of other causes: oligoovulation
and/or anovulation, clinical or biochemical hyperandrogenism, and polycystic ovaries detected by ultrasound .
For a diagnosis of PCOS, two of the following three criteria must be met: oligoovulation
and/or anovulation, clinical or biochemical signs of excess androgen activity, polycystic ovaries on ultrasound (greater than or equal to 12 follicles 2-9 mm in size or the volume is greater than 10 mL).
5] Anovulation & oligoovulation
resulting in hyperestrinism, cause prolonged stimulation of the endometrial lining and increase the risk of both endometrial hyperplasia and carcinoma.
According to the most widely used diagnostic criteria (Rotterdam Criteria for Diagnosis of PCOS), at least two of the following need to be present to confirm a diagnosis (after excluding other causes): oligoovulation
and/or anovulation (associated with irregular (or cessation of) menstruation), hyperandrogenism (demonstrated clinically by increased body hair, and in more severe cases, hair loss), and polycystic ovaries, with the exclusion of other aetiologies.
Evidence of oligoovulation
was provided by serum luteal phase progesterone measurements <4 [micro]g/L (12.
In women who experience oligoovulation
or anovulation, ovulation induction is typically offered.
Polycystic ovary syndrome (PCOS) is characterized by androgen excess and oligoovulation
The diagnosis is made when two out of three components are present, such as hyperandrogenism, polycystic ovaries and oligoovulation
Treatment with VPA was associated with an increased incidence of PCOS in the criteria that related to hyperandrogenism, oligoovulation
with two of the following three conditions fulfilled: ultrasonography of polycystic ovarian structure, the increased serum testosterone levels and menstrual cycle disorder (oligo/amenorrhea).
Obese women who suffer from oligoovulation
may also benefit from the progestin in combined OCs, which can mitigate the effects of unopposed estrogen.
In the case of anovulation or oligoovulation
, once pregnancy is ruled out, the patient's estrogen status should be assessed with a progestin challenge test,