Laurent et al  was the first to show the promising biological properties of Biodentine on human fibroblast cultures and reported that angiogenesis, recruitment of progenitor cell by inducing odontoblasts
differentiation, and cell differentiation generates deposition of a reactionary dentine as well as dense dentine bridge.
Similarly to DPSC analysis, the research of stem cells from apical papilla (SCAP) have shown that those cells also have the ability to differentiate into functional odontoblasts
, which has confirmed the multipotent character of both those cell lines.
The cavity preparation induces destructive changes in odontoblasts
at the affected site followed by pulp mesenchymal cell migration to the damaged odontoblast
layer and differentiation into new odontoblasts
(Izumi, Eida, Matsumoto, & Inoue, 2007).
This is possible because of the presence of progenitor/stem cells in the dental pulp, which are able to form odontoblasts
under appropriate microenviron-ments (Hao et al.
They have the capability to differentiate into osteoblasts, odontoblasts
, endothelial cells, adipocytes, and neural cells (10-13).
Similarly, in the dental mesenchyme, Dll1 is expressed in odontoblasts
in process of differentiation, while NOTCH genes are expressed in the sub-odontoblastic layer mainly.
As observed in humans, the dentin is produced by odontoblasts
(Figure 2E) and the thickness is enhanced at the incisal region.
Descriptive analysis of microscopic sections taken from primary teeth in the process of root resorption, stained by hematoxylin-eosin, showed a loose connective tissue with a variable number of fibroblast-like cells, odontoblasts
and undifferentiated mesenchymal cells dispersed among collagen fibers, blood vessels and nerve fibers in the coronary
Dentine, produced by odontoblasts
, is chiefly composed of calcium phosphate minerals, fibrous proteins, and collagen.
Vitamin A plays a crucial role in the formation of ameloblasts and odontoblasts
As the odontoblasts
express BMP, it induces ameloblasts to differentiate.
Daha cok olgun osteoblastlar tarafindan sentezlenmesinin yaninda osteosit, hIpertrofik kondrosit, sementoblast ve odontoblasts
tarafindan da sentezlenir (26).