ocular hypertension


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Related to ocular hypertension: glaucoma, ocular migraine

ocular hypertension

a condition of intraocular pressure that is higher than normal but that has not resulted in a constricted visual field or increased cupping of the optic nerve head. See also glaucoma.

ocular hypertension

Increased intraocular pressure, typically exceeding 21 mm Hg. This condition, present in glaucoma, may predispose affected persons to optic nerve damage and visual field loss.
See also: hypertension

hypertension, ocular

A condition in which the intraocular pressure (IOP) is above normal (>21 mmHg) but in which there are neither visual field defects nor optic disc changes. Open-angle glaucoma may or may not develop later: risk factors include thin central corneal thickness, large cup/disc ratio, high IOP and lack of treatment to reduce IOP greater than 30 mmHg.

hypertension

persistently high blood pressure. Detected sporadically in animals partly due to the technical difficulties in diagnosis and the lack of recognizable signs. Greyhounds normally have a higher blood pressure than is found in crossbred dogs with features resembling essential hypertension in humans. Secondary hypertension due to advanced renal disease, hyperthyroidism and hyperadrenocorticism does occur in dogs and cats. Temporary episodes of hypertension occur in all animals suffering severe pain, and in horses with acute laminitis.

endocrine hypertension
that occurring in association with diseases of the endocrine glands.
Goldblatt hypertension
see Goldblatt kidney.
inherited hypertension
see rat hypertension (below).
neurogenic hypertension
produced experimentally in laboratory animals by the imposition of surgical and psychological insults on the central nervous system.
ocular hypertension
persistently elevated intraocular pressure in the absence of any other signs of glaucoma; it may or may not progress to chronic simple glaucoma.
portal hypertension
abnormally increased pressure in the portal circulation caused by impedance of blood flow through a diseased liver or portal vein.
pulmonary hypertension
results from high-pressure blood flow from the right ventricle or impedance to blood flow through the lungs or through the left heart. Chronic hypertension causes endothelial degeneration and fibroplasia of vessel walls. The end result may be cor pulmonale or pulmonary edema. See also altitude sickness, cor pulmonale.
rat hypertension
several strains of spontaneously hypertensive rats have been bred.
renal hypertension
secondary hypertension.
systemic venous hypertension
elevation of systemic venous pressure, usually detected by inspection of the jugular veins.
References in periodicals archive ?
In all species studied to date, ocular hypertension is invariably caused by impaired aqueous humor outflow rather than by hypersecretion.
Nicox's key proprietary asset in ophthalmology is VESNEO (latanoprostene bunod) (latanoprostene bunod), a novel compound based on Nicox's proprietary nitric oxide (NO)-donating R&D platform, currently in Phase 3 clinical development in collaboration with Bausch + Lomb for the potential treatment of glaucoma and ocular hypertension.
Ocular Hypertension Phase 2 Clinical Trial Pipeline Insights
The recently completed Phase II trial was a multi-center, randomized, double-masked, placebo-controlled, dose-ranging study to evaluate the safety, tolerability, pharmacokinetics, and efficacy of trabodenoson delivered as an eye-drop formulation in patients with primary open-angle glaucoma or ocular hypertension.
The Company has completed enrollment of over 160 subjects in its randomized, active controlled Phase 2 Study of the Helios insert in patients with glaucoma and ocular hypertension.
However, Mr Roberson pointed out that it was the worry over diagnosis of ocular hypertension which was the main concern, which was signalled last year.
The recently completed Phase 2 trial was a multi-center, randomized, double-masked, placebo-controlled, dose-ranging study to evaluate the safety, tolerability, pharmacokinetics, and efficacy of trabodenoson delivered as an eye-drop formulation in patients with primary open-angle glaucoma or ocular hypertension.
Patients with documented ocular hypertension or open-angle glaucoma, the most common form of the disease, will be evaluated for reduction of intraocular pressure from baseline and retention of the plug through two months.
com/research/3f7c41/global_ocular_hype) has announced the addition of the "Global Ocular Hypertension Drug Pipeline Capsule - 2012" report to their offering.
com/research/fe7e39/global_ocular_hype) has announced the addition of the "Global Ocular Hypertension Drug Pipeline Capsule - 2011" report to their offering.
a world leader in the discovery and development of RNAi-based therapeutics, today announced results from a second study of QPI-1007, a neuroprotective siRNA drug, in rat ocular hypertension model of glaucoma, conducted by Prof.