obesogen


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obesogen

An exogenous substance that alters lipid homeostasis and fat storage, changes metabolic setpoints, disrupts energy balance or modifies the regulation of appetite and satiety, promoting fat accumulation and obesity.

Mechanisms of action
Alteration of metabolic sensing, neuroendocrine effects, cell signalling, dysregulation of steroid hormones.

Obesogens
Pharmaceutical obesogens
• Metabolic sensors—Act on PPAR-gamma receptor (e.g., thiazolidinediones, rosiglitazone);
• Sex steroid dysregulation—DES caused obesity in adults;
• Central—Act on neurotransmitter receptors (e.g., SSRIs, antidepressants).

Environmental obesogens
• Organotin;
• Xernobiotics.
References in periodicals archive ?
2014) suggest that FM550 is an endocrine disruptor and an environmental obesogen in murine cell cultures and animal models, little is known regarding its effects on human health and obesity.
Expression of obesity markers and persistent organic pollutants levels in adipose tissue of obese patients: reinforcing the obesogen hypothesis?
Triflumazole is an obesogen in mice that acts through peroxisome proliferator activated receptor gamma (PPAR[gamma]).
Our study suggests that BPA could be a potential new environmental obesogen, a chemical compound that can disrupt the normal development and balance of lipid metabolism, which can lead to obesity," Dr.
The two primary bodies of evidence were integrated using the hazard identification scheme to provide a preliminary classification of the obesogen hazard identified for DDTs ("known," "presumed," "suspected," or "not classifiable" hazard for humans; Figure 1).
Blumberg categorizes TBT as an obesogen, a class of chemicals that promote obesity by increasing the number of fat cells and the storage of fat in existing cells or by altering metabolic regulation of appetite and satiety.
Transgenerational inheritance of increased fat depot size, stem cell reprogramming, and hepatic steatosis elicited by prenatal exposure to the obesogen tributyltin in mice.
Prenatal exposure to the environmental obesogen tributyltin predisposes multipotent stem cells to become adipocytes.
Polychlorinated biphenyl 153 is a diet-dependent obesogen that worsens non-alcoholic fatty liver disease in male C57BL6/J mice.
2012) and triphenyltin is a known obesogen (Kanayama et al.