obesogen


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obesogen

An exogenous substance that alters lipid homeostasis and fat storage, changes metabolic setpoints, disrupts energy balance or modifies the regulation of appetite and satiety, promoting fat accumulation and obesity.

Mechanisms of action
Alteration of metabolic sensing, neuroendocrine effects, cell signalling, dysregulation of steroid hormones.

Obesogens
Pharmaceutical obesogens
• Metabolic sensors—Act on PPAR-gamma receptor (e.g., thiazolidinediones, rosiglitazone);
• Sex steroid dysregulation—DES caused obesity in adults;
• Central—Act on neurotransmitter receptors (e.g., SSRIs, antidepressants).

Environmental obesogens
• Organotin;
• Xernobiotics.
References in periodicals archive ?
In this issue of EHP, researchers suggest that altered lipid transport from the maternal organism to the egg by a known obesogen may be responsible for reproductive problems in Daphnia magna, a tiny freshwater crustacean.
Our study suggests that BPA could be a potential new environmental obesogen, a chemical compound that can disrupt the normal development and balance of lipid metabolism, which can lead to obesity," Dr.
Other research has found that the anti-diabetes drug rosiglitazone both increases the risk of bone fracture and acts as an obesogen, (7) and tributyltin has been shown to induce adipogenesis and suppress osteogenesis.
Blumberg categorizes TBT as an obesogen, a class of chemicals that promote obesity by increasing the number of fat cells and the storage of fat in existing cells or by altering metabolic regulation of appetite and satiety.
These data suggest that a component, or components, of FM550 is acting as an environmental obesogen, a chemical that disrupts the homeostatic controls of adipogenesis and energy balance (Grun et al.
Although some animal studies suggest that BPA is a candidate obesogen, others do not (reviewed by Harley et al.
Polychlorinated biphenyl 153 is a diet-dependent obesogen that worsens nonalcoholic fatty liver disease in male C57BL6/J mice.
Arsenic is not an obesogen, but rather has antiobesogenic properties, although the mechanism remains unknown (Paul et al.
Transgenerational inheritance of increased fat depot size, stem cell programming, and hepatic steatosis elicited by prenatal exposure to the obesogen tributyltin in mice.
15) Like other transgenerational toxicants, TBT is an endocrine disruptor that appears to be an obesogen, or a chemical that promotes obesity partly by promoting the growth of fat cells.
Many animal studies have linked perinatal exposure to environmentally relevant levels of BPA with increased body mass, suggesting it may be an obesogen.