number needed to treat


Also found in: Acronyms, Wikipedia.

number needed to treat

In a clinical treatment regimen, the numeric cohort of patients who must be treated to prevent the occurrence of specified complications or adverse outcomes of the condition under examination.

number needed to treat

Decision-making The minimum number of Pts to whom a particular intervention must be administered in a trial or controlled study to prevent a single target event. See Absolute risk reduction, Odds ratio, Relative risk reduction, Threshold NNT.

number needed to treat

The number of patients who must receive a specific therapy (or undergo a specific medical test) so that one of them will benefit. This concept is important in assessing the relative values and costs of interventions for specific illnesses. For example, to prevent one death from breast cancer, the number of patients who need annual mammography can be calculated. Similarly, the number of patients with cancer who will survive because of the use of a particular chemotherapy can be assessed. Generally, the smaller the number needed to treat, the greater the value of the intervention. This comparative information can be used to decide how to allocate resources, plan studies, or make recommendations to patients about their care.
Mentioned in ?
References in periodicals archive ?
The absolute risk reduction and the number needed to treat will vary according to the predictive value of the risk factor, while the relative risk reduction may not.
Trial evidence would suggest that its benefit is limited to reduction of awareness in high-risk individuals if one is prepared to accept a very large number needed to treat in that regard.
The number needed to treat (NNT) in order for one patient to gain significant benefit from physiotherapy plus education was calculated for both pain reduction and disability reduction.
This translates into a clinically relevant number needed to treat (NNT) of 3.
Determination of Number Needed to Treat With Lorcaserin to Achieve HbA1c Reductions of >/=0.
For 1 patient to be prevented from resuming any drinking, the number needed to treat was only 12 with acamprosate and only 20 for oral naltrexone.
Without a randomized controlled trial to evaluate stillbirth, and weighing the gravity of stillbirth against the morbidities of early-term delivery, given the favorable number needed to treat to prevent one stillbirth, we advocate delivery of SGA pregnancies in the 37th week and not beyond the 38th week," she said.
Stratifying the Study According to KIF6 Status Demonstrated Increased Effectiveness of Statin Therapy in KIF6 Carriers: the Number Needed to Treat to Prevent One CHD Event was 16 in Carriers Compared With 83 in Noncarriers
The researchers calculated the number needed to treat for an additional harm at 165 women for stroke, 118 for venous thromboembolism, and 242 for pulmonary embolism.
The number needed to treat to achieve one recovery in this group was just three, Steven D.
The number needed to treat at 20 mg/ day for 5 years in order to prevent one additional case of breast cancer was calculated at 95 in 5 years and 56 in 10 years.