BPTF

(redirected from nucleosome-remodelling factor subunit BPTF)

BPTF

A gene on chromosome 17q24.3 that encodes a histone-binding component of nucleosome-remodelling factor (NURF), a protein complex which catalyses ATP-dependent nucleosome sliding and facilitates transcription.

Molecular pathology
High levels of FAC1/BPTF may be found in foetal brain and in patients with neurodegenerative diseases (e.g., Alzheimer’s disease).