nucleoside reverse transcriptase inhibitors


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Related to nucleoside reverse transcriptase inhibitors: Protease inhibitors

nucleoside reverse transcriptase inhibitors (NRTI)

a class of antiretroviral drugs that mimic one or more of the components of deoxyribonucleic acid (DNA) or ribonucleic acid and interrupt the viral replication process. The drugs (nucleoside analogs) work by being incorporated into the DNA made by the viral reverse transcriptase enzyme that is essential for viral replication. Inserting a nucleoside analog into the new viral DNA strand terminates the viral chain, halting the replication process before it is completed. Examples of nucleoside analogs include zidovudine (AZT), didanosine (ddI), zalcitabine (ddC), stavudine (d4T), and lamivudine (3TC). See also nonnucleoside reverse transcriptase inhibitors.

nu·cle·o·side re·verse tran·scrip·tase in·hib·i·tors

(NRTIs) (nyū'klē-ō-sīd rĕ-vĕrs' trans-krip'tās in-hib'i-tŏrz)
Class of medications to treat HIV infection (e.g., zidovudine, lamivudine).

nucleoside reverse transcriptase inhibitors

Drugs used to treat HIV infections in combination with other drugs. Examples are abacavir (Ziagen), didanosine (Videx, Videx EC), lamivudine (Combivir, Epivir), stavudine (Zerit), zalcitabine (Hivid) and zidovudine (Retrovir). The brand Trizivir contains abacavir, lamivudine and zidovudine.
References in periodicals archive ?
Nucleoside reverse transcriptase inhibitors (NRTIs) in particular have been associated with lactic acidosis (elevated levels of lactic acid in the blood) and hepatic steatosis (fatty liver).
In this study, PA-457's anti-HIV activity was tested against a number of commonly occurring HIV strains resistant to approved drugs including nucleoside reverse transcriptase inhibitors (NRTIs), non-NRTIs, protease inhibitors, and fusion inhibitors.
New reports suggest that zidovudine resistance mutations may be important for resistance to other nucleoside reverse transcriptase inhibitors (NRTIs), and a novel mechanism for resistance has been described.
Previously, she held product marketing positions at Bristol-Myers-Squibb in virology, where she was in charge of two nucleoside reverse transcriptase inhibitors (NRTIs) Zerit(R) and Videx(R) for treatment of HIV, and at Bayer Pharma, where she was involved with the launch of Glucor(R) for treatment of diabetes.
The regimens that have been best documented to work in this context are built on a backbone of ritonavir (Norvir) and saquinavir (Fortovase) along with nucleoside reverse transcriptase inhibitors (NRTIs).
Two nucleoside reverse transcriptase inhibitors (NRTIs) were added afterward (specific drugs not listed).
saquinavir (Fortovase) plus 2 nucleoside reverse transcriptase inhibitors (NRTIs),
The drugs are grouped according to class: nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors.
Nevirapine was granted accelerated approval for use in combination with nucleoside reverse transcriptase inhibitors (NRTIs) by the US Food & Drug Administration (FDA) in June 1996.
Amex:ANX) today announced data from an in vitro study indicating that Thiovir(TM), the Company's non-nucleoside reverse transcriptase inhibitor (NNRTI), demonstrated effectiveness against human immunodeficiency virus type-1 (HIV-1), which is resistant to other NNRTIs and nucleoside reverse transcriptase inhibitors (NRTIs).
The US Food & Drug Administration (FDA) approved it in its first formulation (saquinavir hard-gel, saquinavir mesylate or Invirase) for use in combination with nucleoside reverse transcriptase inhibitors (NRTIs) in December 1995.
They then added nevirapine (Viramune) and at least 1 nucleoside reverse transcriptase inhibitor (NRTI).

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