nucleoside reverse transcriptase inhibitor


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nucleoside reverse transcriptase inhibitor

n. Abbr. NRTI
Any of a group of antiviral drugs, such as stavudine, that interfere with the activity of the enzyme reverse transcriptase, are structural analogs of natural nucleosides, and are used chiefly to treat HIV infection.

nucleoside reverse transcriptase inhibitor

Abbreviation: NRTI
Any of a class of antiretroviral drugs used to treat patients with HIV infection. NRTIs prevent transcription of viral RNA to host DNA by interfering with the action of the enzyme reverse transcriptase. Zidovudine, dideoxyinosine, zalcitabine, d4T, and abacavir are NRTIs. See: reverse transcriptase inhibitor
See also: inhibitor
References in periodicals archive ?
If approved by regulatory authorities, the two drug fixed-dose combination therapy being developed by ViiV Healthcare and Janssen could offer people living with HIV an option to switch from a standard three drug therapy to a two drug nucleoside reverse transcriptase inhibitors (NRTI)-sparing combination, once a stable suppressed viral load has been achieved.
After 24 weeks, the combination of Invirase, Agenerase, and Norvir plus nucleoside reverse transcriptase inhibitors (NRTIs or "nukes") decreased viral load and increased T cell count.
Also, among patients on multiple nucleoside reverse transcriptase inhibitors, platelet counts of less than 99,000/m[m.
In addition, ZDV and 3TC caused fewer adverse effects than combinations with different nucleoside reverse transcriptase inhibitors, didanosine (ddI) and stavudine (d4T).
However, while we know resistance can slow this virus down--we all know resistant virus can win; look at what happened in the era of treating with just nucleoside reverse transcriptase inhibitors (NRTIs) and the ongoing deaths from uncontrolled HIV.
Newer drugs are selecting for different types of resistance, especially in nucleoside reverse transcriptase inhibitors (NRTIs), so that there may not be large numbers of thymidine analog mutations (TAMs) developing in patients who have started therapy in recent years.
Surprisingly, support for this notion has come from testing the effect of removing single drugs from a failing regimen--in particular, nucleoside reverse transcriptase inhibitors (NRTIs).
Each dose of Trizivir is a fixed-dose combination of Ziagen (abacavir/ABC), Retrovir (zidovudine/AZT), and Epivir (lamivudine/3TC), three nucleoside reverse transcriptase inhibitors (NRTIs) already approved by FDA.
However, these 25 patients, all of whom were naive to non-nucleoside reverse transcriptase inhibitors (NNRTIs), were given efavirenz (Sustiva), a potent NNRTI, in addition to Kaletra and nucleoside reverse transcriptase inhibitors (NRTIs).

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