The NSP2 protein functions as a single-stranded RNA binding protein, nucleic acid helix destabilizer, nucleoside triphosphatase (NTP), nucleoside diphosphate kinase
(NDP), and RNA triphosphatase (RTPase) (2).
Down-regulation of expression and function of nucleoside diphosphate kinase
in insulin-secreting beta-cells under in vitro conditions of glucolipotoxicity.
suggest that the role NM23 in oncogenesis and tumour metastasis could be related to its nucleoside diphosphate kinase activity .
Expression in human hepatocellular carcinoma of nucleoside diphosphate kinase, a homologue of the nm23 gene product.
These confirmed proteins include cathepsin D, nucleoside diphosphate kinase 1, fatty acid binding protein 5, oncogene DJ1, and peroxiredoxin 5.
PARK7 and nucleoside diphosphate kinase A as plasma markers for the early diagnosis of stroke.
Ridge, Three-Dimensional Structure of Two Isoforms of Nucleoside Diphosphate Kinase
from Bovine Retina, Acta Crystallogr.
Proteomic analysis of postmortem cerebrospinal fluid identified nucleoside diphosphate kinase
A and PARK7 as proteins released by brain injury and as potential new biomarkers for stroke (13).
Still, it is of great interest that PARK7 and nucleoside diphosphate kinase
A were increased in acute stroke patients.
Human brain nucleoside diphosphate kinase activity is decreased in Alzheimer's disease and Down syndrome.
5] Nonstandard abbreviations: CT, computerized tomography; MRI, magnetic resonance imaging; TIA, transient ischemic attack; CSF, cerebrospinal fluid; NDKA, nucleoside diphosphate kinase A; CI, confidence interval; and NDP, nucleoside diphosphate.