nucleoside analogue


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analogue

 [an´ah-log]
1. a part or organ having the same function as another, but of different evolutionary origin.
2. a chemical compound having a structure similar to that of another but differing from it in respect to a certain component; it may have similar or opposite action metabolically. Also spelled analog.
nucleoside analogue a structural analogue of a nucleoside, a category that includes both purine analogues and pyrimidine analogues.
purine analogue a structural analogue of one of the purine bases(purine, adenine, or guanine); mercaptopurine and thioguanine are used as antineoplastics and azathioprine is an immunosuppressive. The antiviral agent vidarabine is an analogue of the adenine nucleoside adenosine.
pyrimidine analogue a structural analogue of one of the pyrimidine bases(cytosine, thymine, or uracil); fluorouracil and cytarabine are important antineoplastic agents.

nucleoside analogue

Molecular medicine An artificial nucleoside which, when incorporated into viral DNA during replication, prevents production of new virus; NAs can inhibit DNA production in healthy cells; a molecule that structurally mimics a nucleoside. See AIDS, Zidovudine.

nucleoside analogue

A drug that resembles a NUCLEOSIDE and that can be taken up in place of the natural nucleosides in viruses so as to form DNA that is fragile and susceptible to breakage. Drugs of this class, which include IDOXURIDINE, FAMCICLOVIR, DIDANOSINE and PENCICLOVIR, require the action of an enzyme carried by the target virus, before they become functional.
References in periodicals archive ?
A major problem with nucleoside analogue HIV therapy is that the HIV virus readily develops resistance to drugs of this class with resulting drug failures.
NNRTIs (see Table 2) are indicated for treating HIV-1 infected adults in combination with nucleoside analogues.
Nucleoside analogues are usually administered for at least 6 months after the patient has developed anti-HBe, in HBeAg-positive patients, and until clearance of HBsAg in HBeAgnegative patients.
Approved March 14, 1997 for the use of alone or in combination with nucleoside analogues for the treatment of HIV infection in selected patients.
Approved December 7, 1995 for combination use with nucleoside analogues for the treatment of advanced HIV infection in selected patients.
Nucleoside analogues are the preferred choice of treatment for physicians in Indonesia due to their efficacy, cost, and lower resistance.
Nucleoside analogues are likely to continue to experience strong growth as most clinical trials are in the area of nucleoside analogues.
Surprisingly, hepatitis C viral loads increased significantly more in HAART patients during the observational period than in those who received nucleoside analogues or no therapy.
A trend toward higher weight loss was seen in patients who received didanosine or stavudine, compared with those who received other nucleoside analogues (N.
Of the 195 patients in the study, those switched to two nucleoside analogues (one of which was new for the patient) plus nelfinavir and efavirenz had a higher rate of viral suppression than those treated with nucleoside analogues plus nelfinavir or efavirenz, Dr.

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